Browsing FAS Theses and Dissertations by Keyword "53BP1"
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Elucidating Mechanisms of IgH Class Switch Recombination Involving Switch Regions and Double Strand Break Joining
(2013-02-22)During IgH class switch recombination (CSR) in mature B lymphocytes, activation-induced cytidine deaminase (AID) initiates DNA double strand breaks (DSBs) within switch (S) regions flanking different sets of the IgH locus ... -
The regulatory functions of TIRR in DNA repair and p53-mediated cell fate
(2021-05-12)The tumor suppressor protein, TP53BP1, is an important DNA double-strand break (DSB) repair protein that is extensively regulated by post-translational modifications and protein-protein interactions. Our lab and others ...