Browsing FAS Theses and Dissertations by FAS Department "Chemistry and Chemical Biology"
Now showing items 1-20 of 149
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1,2-Selective Hydrosilylation of Conjugated Dienes
(2014-06-06)Selective 1,2-hydrosilylation of 1,3-dienes is a challenging problem to solve for transition metal catalysis. Butadiene, specifically, would be a useful substrate because 3-butenylsilane products have promise as superior ... -
A Framework for Protein-Level Interpretation of Genetic Associations and Integration With Large-Scale DNA Sequencing Analysis
(2017-05-10)With recent rapid decrease in exome and genome sequencing price amount of the available sequencing data has dramatically increased. While analysis of common genetic variation has succeeded with GWAS and fine-mapping ... -
A Platform for the Discovery of New Lincosamide Antibiotics
(2018-05-10)This dissertation presents a flexible synthetic approach to the lincosamide antibiotics, developed with the aim of rejuvenating an underexploited class to combat multidrug-resistant bacterial pathogens. The only clinically ... -
Activation of Electron-Deficient Quinones Through Hydrogen-Bond-Donor-Coupled Electron Transfer
(2015-09-23)Quinones are organic oxidants that play important roles in biological contexts and find wide application in organic synthesis. They are known to be activated toward electron transfer through hydrogen bonding, which has ... -
Activation of Weak Nucleophiles in Anion-Binding Catalysis
(2016-09-14)Anion-binding catalysis has emerged as a powerful principle for the development of highly enantioselective transformations. This strategy relies on the ability of dual hydrogen-bond donors to promote anion abstraction from ... -
Advanced Metallization Processes for Complex Structures in Microelectronics by Direct-Liquid-Evaporation Chemical Vapor Deposition
(2017-07-27)With the rapid advancement of semiconductor industry, fabrications of complex microelectronic devices are going beyond the conventional planar geometries into three-dimensionality (3D). Besides, since the emerging of ... -
Advanced Physical Techniques in Inorganic Chemistry: Probing Small Molecule Activation
(2016-05-16)Robust and efficient catalysts are necessary for realizing chemical energy storage as a solution for the intermittency associated with renewable energy sources. To aid in the development of such catalysts, physical methods ... -
Advances in Crystal Growth and Assembly for Imparting Novel Photonic Properties to Semiconductor Nanowires
(2015-08-17)Semiconductor nanowires comprise a versatile materials platform with which to characterize the properties of nanomaterials. The vast range of structural and compositional diversity of nanowires has also enabled their use ... -
An antibiotic binds to the ATPase that powers lipopolysaccharide transport
(2016-07-05)The spread of antibiotic resistance has created an urgent need for new antibiotics. The situation is particularly serious for Gram-negative bacteria because they possess an outer membrane (OM) that prevents many antibiotics ... -
Biochemical and Crystallographic Studies of the Escherichia Coli β-Barrel Assembly Machine
(2016-09-01)Bacteria have developed resistance mechanisms to every class of antibiotics that has been created and combating the rise of multidrug-resistant bacteria—a major threat to public health—requires the continual development ... -
The Biochemistry and Physiology of Peptidases
(2013-03-14)Peptidases regulate important physiological processes by controlling levels of bioactive peptides and occasionally through noncatalytic processes. This thesis presents a study of prolyl endopeptidase-like (PREPL), which ... -
Biomimetics through nanoelectronics: development of three-dimensional macroporous nanoelectronics for building smart materials, cyborg tissues and injectable biomedical electronics.
(2014-06-06)Nanoscale materials enable unique opportunities at the interface between physical and life sciences. The interface between nanoelectronic devices and biological systems makes possible communication between these two diverse ... -
C-H Amination Catalysis from High-Spin Ferrous Complexes
(2013-10-15)The C-H amination and olefin aziridination chemistry of iron supported by dipyrromethene ligands (RLAr, L=1,9-R2-5-aryldipyrromethene, R = Mes, 2,4,6-Ph3C6H2, tBu, Ad, 10-camphoryl, Ar = Mes, 2,4,6-Cl3C6H2) was explored. ... -
Cell-Based Discovery Methods Furnish New Compounds Effective Against Gram-Negative Bacteria
(2016-07-20)Bacterial resistance to antibiotics inevitably results from their clinical use, and we have to continuously develop new antibiotics to stay ahead in this biological arms race. It is particularly important and challenging ... -
Chemical and Cellular Defenses against Foreign Pathogens
(2012-09-07)Bacterial and viral infections affect billions of people each year. While bacterial infections are treated by the use of antibiotics, viral infections are eradicated by the immune system. This thesis comprises two parts. ... -
A Chemical Approach Identifies CDK4 as a Regulatory Component of Glucose Metabolism
(2014-06-06)Mammals have to adapt quickly to the changes of nutrition availability. The liver is the central organ that coordinates the responses to food deprivation upon fasting and nutrient overload during feeding. In liver, hormonal ... -
Chemical Approaches to the Surface Engineering of Paper and Cellulose-Based Materials for Microfluidics, Electronics and Low-Cost Diagnostics
(2016-01-27)Paper (and other cellulose-based materials such as cotton thread and fabrics) are underexploited as materials for the construction of “high-tech” and “lab-on-a-chip” devices. One major drawback of paper is its tendency to ... -
Chemical Neurobiology of the Histone Lysine Demethylase KDM1A
(2016-05-18)Epigenetic mechanisms regulate gene expression and mediate interactions between genetic factors and environmental exposures. The enzymes responsible for epigenetic regulation may thus be important therapeutic targets for ... -
Chemical Vapor Deposition of Thin Film Materials for Copper Interconnects in Microelectronics
(2012-07-24)The packing density of microelectronic devices has increased exponentially over the past four decades. Continuous enhancements in device performance and functionality have been achieved by the introduction of new materials ... -
Component-Based Syntheses of Trioxacarcins
(2014-06-06)The trioxacarcins are structurally complex, highly oxygenated bacterial isolates that potently inhibit the growth of human cancer cells in culture as a consequence of their ability to alkylate guanosine residues of duplex ...