Burning Cold: Involvement of TRPA1 in Noxious Cold Sensation

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Burning Cold: Involvement of TRPA1 in Noxious Cold Sensation

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Title: Burning Cold: Involvement of TRPA1 in Noxious Cold Sensation
Author: Kwan, Kelvin Y; Corey, David Paul

Note: Order does not necessarily reflect citation order of authors.

Citation: Kwan, Kelvin Y., and David P. Corey. 2009. Burning cold: involvement of TRPA1 in noxious cold sensation. The Journal of General Physiology 133(3): 251-256.
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Abstract: Soon after its discovery ten years ago, the ion channel TRPA1 was proposed as a sensor of noxious cold. Evidence for its activation by painfully cold temperatures (below ~15° C) has been mixed, however. Some groups found that cold elicits a nonselective conductance in cells expressing TRPA1; others found no activation, or argued that activation is an indirect effect of elevated \(Ca^{ 2+}\) . Sensory cells from the trigeminal and dorsal root ganglia that are activated by cold were sometimes correlated with those cells expressing TRPA1; other times not. Mice lacking TRPA1 showed behavioral defi cits for some assays of painful cold sensation, but not others. New evidence tends to support direct activation of TRPA1 by cold, and the slow and relatively weak activation of TRPA1 by cold helps reconcile some confl icting studies.
Published Version: doi:10.1085/jgp.200810146
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654090/pdf/
www.jgp.org/cgi/doi/10.1085/jgp.200810146
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:5025178

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