Effect of lung compliance and endotracheal tube leakage on measurement of tidal volume

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Effect of lung compliance and endotracheal tube leakage on measurement of tidal volume

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dc.contributor.author Al-Majed, Sami I.
dc.contributor.author Watson, Kenneth F.
dc.contributor.author Thompson, John E.
dc.contributor.author Randolph, Adrienne G.
dc.date.accessioned 2011-07-26T02:13:06Z
dc.date.issued 2004
dc.identifier.citation Al-Majed, Sami I, John E Thompson, Kenneth F Watson, and Adrienne G Randolph. 2004. Effect of lung compliance and endotracheal tube leakage on measurement of tidal volume. Critical Care 8(6): R398-R402. en_US
dc.identifier.issn 1364-8535 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:5030329
dc.description.abstract Introduction: The objective of this laboratory study was to measure the effect of decreased lung compliance and endotracheal tube (ETT) leakage on measured exhaled tidal volume at the airway and at the ventilator, in a research study with a test lung. Methods: The subjects were infant, adult and pediatric test lungs. In the test lung model, lung compliances were set to normal and to levels seen in acute respiratory distress syndrome. Set tidal volume was 6 ml/kg across a range of simulated weights and ETT sizes. Data were recorded from both the ventilator light-emitting diode display and the CO2SMO Plus monitor display by a single observer. Effective tidal volume was calculated from a standard equation. Results: In all test lung models, exhaled tidal volume measured at the airway decreased markedly with decreasing lung compliance, but measurement at the ventilator showed minimal change. In the absence of a simulated ETT leak, calculation of the effective tidal volume led to measurements very similar to exhaled tidal volume measured at the ETT. With a simulated ETT tube leak, the effective tidal volume markedly overestimated tidal volume measured at the airway. Conclusion: Previous investigators have emphasized the need to measure tidal volume at the ETT for all children. When ETT leakage is minimal, it seems from our simulated lung models that calculation of effective tidal volume would give similar readings to tidal volume measured at the airway, even in small patients. Future studies of tidal volume measurement accuracy in mechanically ventilated children should control for the degree of ETT leakage. en_US
dc.language.iso en_US en_US
dc.publisher BioMed Central en_US
dc.relation.isversionof doi://10.1186/cc2954 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1065056/pdf/ en_US
dash.license LAA
dc.subject intensive care en_US
dc.subject lung compliance en_US
dc.subject mechanical ventilation en_US
dc.subject monitoring tidal volume en_US
dc.title Effect of lung compliance and endotracheal tube leakage on measurement of tidal volume en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Critical Care en_US
dash.depositing.author Randolph, Adrienne G.
dc.date.available 2011-07-26T02:13:06Z
dash.affiliation.other HMS^Anaesthesia-Children's Hospital en_US

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