Gefitinib and High-Dose Fractionated Radiotherapy for Carcinomatous Encephalitis from Non-Small Cell Lung Carcinoma

Gefitinib and High-Dose Fractionated Radiotherapy for Carcinomatous Encephalitis from Non-Small Cell Lung Carcinoma

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Gefitinib and High-Dose Fractionated Radiotherapy for Carcinomatous Encephalitis from Non-Small Cell Lung Carcinoma

dc.contributor.author	Wong, Eric T.
dc.contributor.author	Wu, Julian K.
dc.contributor.author	Mahadevan, Anand
dc.date.accessioned	2011-08-30T13:51:34Z
dc.date.issued	2007
dc.identifier.citation	Wong, Eric T., Julian K. Wu, and Anand Mahadevan. 2007. Gefitinib and high-dose fractionated radiotherapy for carcinomatous encephalitis from non-small cell lung carcinoma. Biologics: Targets & Therapy 1(3): 321-324.	en_US
dc.identifier.issn	1177-5475	en_US
dc.identifier.uri	http://nrs.harvard.edu/urn-3:HUL.InstRepos:5119434
dc.description.abstract	Carcinomatous encephalitis is a rapidly fatal form of metastasis caused by miliary spread of systemic cancer into the brain parenchyma. The diagnostic criteria and optimal treatment for this disease are not well defined. We report a patient with rapid neurologic deterioration from carcinomatous encephalitis from lung adenocarcinoma. She was treated with gefitinib and high-dose fractionated whole brain radiotherapy, and eventually improved neurologically and was discharged home on hospital day 48. Gefitinib and high-dose fractionated radiotherapy may have synergistic activity in patients with carcinomatous encephalitis from non-small cell lung cancer having favorable prognostic factors. More importantly, timely recognition of this disease and the use of large fraction radiation therapy are necessary to control rapid neurologic deterioration.	en_US
dc.language.iso	en_US	en_US
dc.publisher	Dove Medical Press	en_US
dc.relation.hasversion	http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721320/pdf/	en_US
dash.license	LAA
dc.subject	brain metastases	en_US
dc.subject	Gefi tinib	en_US
dc.subject	radiation	en_US
dc.title	Gefitinib and High-Dose Fractionated Radiotherapy for Carcinomatous Encephalitis from Non-Small Cell Lung Carcinoma	en_US
dc.type	Journal Article	en_US
dc.description.version	Version of Record	en_US
dc.relation.journal	Biologics: Targets & Therapy	en_US
dash.depositing.author	Mahadevan, Anand
dc.date.available	2011-08-30T13:51:34Z
dash.affiliation.other	HMS^Radiation Oncology-BIDMC	en_US