Gefitinib and High-Dose Fractionated Radiotherapy for Carcinomatous Encephalitis from Non-Small Cell Lung Carcinoma

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Gefitinib and High-Dose Fractionated Radiotherapy for Carcinomatous Encephalitis from Non-Small Cell Lung Carcinoma

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dc.contributor.author Wong, Eric T.
dc.contributor.author Wu, Julian K.
dc.contributor.author Mahadevan, Anand
dc.date.accessioned 2011-08-30T13:51:34Z
dc.date.issued 2007
dc.identifier.citation Wong, Eric T., Julian K. Wu, and Anand Mahadevan. 2007. Gefitinib and high-dose fractionated radiotherapy for carcinomatous encephalitis from non-small cell lung carcinoma. Biologics: Targets & Therapy 1(3): 321-324. en_US
dc.identifier.issn 1177-5475 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:5119434
dc.description.abstract Carcinomatous encephalitis is a rapidly fatal form of metastasis caused by miliary spread of systemic cancer into the brain parenchyma. The diagnostic criteria and optimal treatment for this disease are not well defined. We report a patient with rapid neurologic deterioration from carcinomatous encephalitis from lung adenocarcinoma. She was treated with gefitinib and high-dose fractionated whole brain radiotherapy, and eventually improved neurologically and was discharged home on hospital day 48. Gefitinib and high-dose fractionated radiotherapy may have synergistic activity in patients with carcinomatous encephalitis from non-small cell lung cancer having favorable prognostic factors. More importantly, timely recognition of this disease and the use of large fraction radiation therapy are necessary to control rapid neurologic deterioration. en_US
dc.language.iso en_US en_US
dc.publisher Dove Medical Press en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721320/pdf/ en_US
dash.license LAA
dc.subject brain metastases en_US
dc.subject Gefi tinib en_US
dc.subject radiation en_US
dc.title Gefitinib and High-Dose Fractionated Radiotherapy for Carcinomatous Encephalitis from Non-Small Cell Lung Carcinoma en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Biologics: Targets & Therapy en_US
dash.depositing.author Mahadevan, Anand
dc.date.available 2011-08-30T13:51:34Z
dash.affiliation.other HMS^Radiation Oncology-BIDMC en_US

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