Novel Association of ABO Histo-blood Group Antigen with Soluble ICAM-1: Results of a Genome-wide Association Study of 6,578 Women

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Novel Association of ABO Histo-blood Group Antigen with Soluble ICAM-1: Results of a Genome-wide Association Study of 6,578 Women

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Title: Novel Association of ABO Histo-blood Group Antigen with Soluble ICAM-1: Results of a Genome-wide Association Study of 6,578 Women
Author: Paré, Guillaume; Kellogg, Mark; Badola, Sunita; Miletich, Joseph P.; Gibson, Greg; Chasman, Daniel Ian; Zee, Robert Yuk Lung; Rifai, Nader; Ridker, Paul M.

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Citation: Pare, Guillaume, Mark Kellogg, Sunita Badola, Joseph P. Miletich, Greg Gibson, Daniel Ian Chasman, Robert Yuk Lung Zee, Nader Rifai, and Paul M. Ridker. 2008. Novel Association of ABO Histo-blood Group Antigen with Soluble ICAM-1: Results of a Genome-wide Association Study of 6,578 Women. PLoS Genetics 4 (7): e1000118.
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Abstract: While circulating levels of soluble Intercellular Adhesion Molecule 1 (sICAM-1) have been associated with diverse conditions including myocardial infarction, stroke, malaria, and diabetes, comprehensive analysis of the common genetic determinants of sICAM-1 is not available. In a genome-wide association study conducted among 6,578 participants in the Women's Genome Health Study, we find that three SNPs at the ICAM1 (19p13.2) locus (rs1799969, rs5498 and rs281437) are non-redundantly associated with plasma sICAM-1 concentrations at a genome-wide significance level (P<5×10\(^{−8}\)), thus extending prior results from linkage and candidate gene studies. We also find that a single SNP (rs507666, P = 5.1×10\(^{−29}\)) at the ABO (9q34.2) locus is highly correlated with sICAM-1 concentrations. The novel association at the ABO locus provides evidence for a previously unknown regulatory role of histo-blood group antigens in inflammatory adhesion processes.
Published Version: doi://10.1371/journal.pgen.1000118
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2432033/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:5129837

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