Effect of Environmental Tobacco Smoke on Levels of Urinary Hormone Markers

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Effect of Environmental Tobacco Smoke on Levels of Urinary Hormone Markers

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dc.contributor.author Wang, Xiaobin
dc.contributor.author Wang, Lihua
dc.contributor.author Yang, Fan
dc.contributor.author Tang, Genfu
dc.contributor.author Xing, Houxun
dc.contributor.author Lasley, Bill
dc.contributor.author Overstreet, James W.
dc.contributor.author Stanford, Joseph B.
dc.contributor.author Chen, ChangFeng
dc.contributor.author Ryan, Louise Marie
dc.contributor.author Xu, Xiang
dc.date.accessioned 2011-09-13T04:14:23Z
dc.date.issued 2005
dc.identifier.citation Chen, Changzhong, Xiaobin Wang, Lihua Wang, Fan Yang, Genfu Tang, Houxun Xing, Louise Ryan, et al. 2005. Effect of environmental tobacco smoke on levels of urinary hormone markers. Environmental Health Perspectives 113(4): 412-417. en_US
dc.identifier.issn 0091-6765 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:5129842
dc.description.abstract Our recent study showed a dose–response relationship between environmental tobacco smoke (ETS) and the risk of early pregnancy loss. Smoking is known to affect female reproductive hormones. We explored whether ETS affects reproductive hormone profiles as characterized by urinary pregnanediol-3-glucuronide (PdG) and estrone conjugate (E1C) levels. We prospectively studied 371 healthy newly married nonsmoking women in China who intended to conceive and had stopped contraception. Daily records of vaginal bleeding, active and passive cigarette smoking, and daily first-morning urine specimens were collected for up to 1 year or until a clinical pregnancy was achieved. We determined the day of ovulation for each menstrual cycle. The effects of ETS exposure on daily urinary PdG and E1C levels in a ±10 day window around the day of ovulation were analyzed for conception and nonconception cycles, respectively. Our analysis included 344 nonconception cycles and 329 conception cycles. In nonconception cycles, cycles with ETS exposure had significantly lower urinary E1C levels (β= –0.43, SE = 0.08, p less than 0.001 in log scale) compared with the cycles without ETS exposure. There was no significant difference in urinary PdG levels in cycles having ETS exposure (β= –0.07, SE = 0.15, p = 0.637 in log scale) compared with no ETS exposure. Among conception cycles, there were no significant differences in E1C and PdG levels between ETS exposure and nonexposure. In conclusion, ETS exposure was associated with significantly lower urinary E1C levels among nonconception cycles, suggesting that the adverse reproductive effect of ETS may act partly through its antiestrogen effects. en_US
dc.language.iso en_US en_US
dc.publisher National Institute of Environmental Health Sciences en_US
dc.relation.isversionof doi:10.1289/ehp.7436 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1278480/pdf/ en_US
dash.license LAA
dc.subject environmental tobacco smoke en_US
dc.subject estrone conjugates (E1C) en_US
dc.subject pregnanediol-3-glucuronide (PdG) en_US
dc.subject prospective study en_US
dc.subject urinary hormone levels en_US
dc.title Effect of Environmental Tobacco Smoke on Levels of Urinary Hormone Markers en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Environmental Health Perspectives en_US
dash.depositing.author Chen, ChangFeng
dc.date.available 2011-09-13T04:14:23Z
dash.affiliation.other HMS^Genetics en_US
dash.affiliation.other SPH^Biostatistics en_US
dash.affiliation.other HMS^Pathology en_US

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