BRAF Activation Initiates but Does Not Maintain Invasive Prostate Adenocarcinoma

DSpace/Manakin Repository

BRAF Activation Initiates but Does Not Maintain Invasive Prostate Adenocarcinoma

Show simple item record

dc.contributor.author Jeong, Joseph H.
dc.contributor.author Wang, Zhenxiong
dc.contributor.author Ouyang, Xuesong
dc.contributor.author Jiang, Shan
dc.contributor.author Guney, Isil
dc.contributor.author Kang, Gyeong Hoon
dc.contributor.author Abate-Shen, Cory
dc.contributor.author Guimaraes, Alexander Savio Ramos
dc.contributor.author Figueiredo, Jose L.
dc.contributor.author Ding, Zhihu
dc.contributor.author Shin, Eyoung
dc.contributor.author Hahn, William C.
dc.contributor.author Loda, Massimo
dc.contributor.author Weissleder, Ralph
dc.contributor.author Chin, Lynda
dc.date.accessioned 2011-10-25T14:36:23Z
dc.date.issued 2008
dc.identifier.citation Jeong, Joseph H., Zhenxiong Wang, Alexander S. Guimaraes, Xuesong Ouyang, Jose L. Figueiredo, Zhihu Ding, Shan Jiang, et al. 2008. BRAF Activation Initiates but Does Not Maintain Invasive Prostate Adenocarcinoma. PLoS ONE 3(12): e3949. en_US
dc.identifier.issn 1932-6203 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:5311766
dc.description.abstract Prostate cancer is the second leading cause of cancer-related deaths in men. Activation of MAP kinase signaling pathway has been implicated in advanced and androgen-independent prostate cancers, although formal genetic proof has been lacking. In the course of modeling malignant melanoma in a tyrosinase promoter transgenic system, we developed a genetically-engineered mouse (GEM) model of invasive prostate cancers, whereby an activating mutation of BRAFV600E–a mutation found in ∼10% of human prostate tumors–was targeted to the epithelial compartment of the prostate gland on the background of Ink4a/Arf deficiency. These GEM mice developed prostate gland hyperplasia with progression to rapidly growing invasive adenocarcinoma without evidence of AKT activation, providing genetic proof that activation of MAP kinase signaling is sufficient to drive prostate tumorigenesis. Importantly, genetic extinction of BRAFV600E in established prostate tumors did not lead to tumor regression, indicating that while sufficient to initiate development of invasive prostate adenocarcinoma, BRAFV600E is not required for its maintenance. en_US
dc.language.iso en_US en_US
dc.publisher Public Library of Science en_US
dc.relation.isversionof doi:10.1371/journal.pone.0003949 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597248/pdf/ en_US
dash.license LAA
dc.subject molecular biology en_US
dc.subject oncology en_US
dc.subject prostate cancer en_US
dc.subject urology en_US
dc.title BRAF Activation Initiates but Does Not Maintain Invasive Prostate Adenocarcinoma en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal PLoS ONE en_US
dash.depositing.author Guimaraes, Alexander Savio Ramos
dc.date.available 2011-10-25T14:36:23Z
dash.affiliation.other HMS^Microbiology and Molecular Genetics en_US
dash.affiliation.other HMS^Medicine-Brigham and Women's Hospital en_US
dash.affiliation.other HMS^Pathology en_US
dash.affiliation.other HMS^Radiology-Massachusetts General Hospital en_US
dash.affiliation.other HMS^Systems Biology en_US
dash.affiliation.other HMS^Dermatology-Brigham and Women's Hospital en_US

Files in this item

Files Size Format View
2597248.pdf 779.5Kb PDF View/Open

This item appears in the following Collection(s)

Show simple item record

 
 

Search DASH


Advanced Search
 
 

Submitters