Assisted Assembly: How to Improve a De Novo Genome Assembly By Using Related Species

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Title:	Assisted Assembly: How to Improve a De Novo Genome Assembly By Using Related Species
Author:	Gnerre, Sante; Lindblad-Toh, Kerstin; Jaffe, David B; Lander, Eric Steven Note: Order does not necessarily reflect citation order of authors.
Citation:	Gnerre, Sante, Eric S Lander, Kerstin Lindblad-Toh, and David B Jaffe. 2009. Assisted assembly: how to improve a de novo genome assembly by using related species. Genome Biology 10(8): R88.
Full Text & Related Files:	2745769.pdf (177.7Kb; PDF)
Abstract:	We describe a new assembly algorithm, where a genome assembly with low sequence coverage, either throughout the genome or locally, due to cloning bias, is considerably improved through an assisting process via a related genome. We show that the information provided by aligning the whole-genome shotgun reads of the target against a reference genome can be used to substantially improve the quality of the resulting assembly.
Published Version:	doi://10.1186/gb-2009-10-8-r88
Other Sources:	http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745769/pdf/
Terms of Use:	This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page:	http://nrs.harvard.edu/urn-3:HUL.InstRepos:5334258