A Revival of the B Cell Paradigm for Rheumatoid Arthritis Pathogenesis?
| Title: | A Revival of the B Cell Paradigm for Rheumatoid Arthritis Pathogenesis? |
| Author: |
Benoist, Christophe O.; Mathis, Diane J.
Note: Order does not necessarily reflect citation order of authors. |
| Citation: | Benoist, Christophe, and Diane Mathis. 2000. A revival of the B cell paradigm for rheumatoid arthritis pathogenesis? Arthritis Research 2(2): 90-94. |
| Full Text & Related Files: |
129991.pdf (204.0Kb; PDF) 
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| Abstract: | Dominant paradigms for the understanding of rheumatoid arthritis (RA) pathogenesis have changed over the years. A predominant role of B lymphocytes, and perhaps of the rheumatoid factor they produced, was initially invoked. In more recent years, recognition of antigens in the joint by T cells sparking an inflammatory cascade has been a more favored interpretation. Here, we re-examine some of the arguments that underpin this proposed role of joint T cells, in light of recent results from transgenic mice in which a self-reactive T-cell receptor provokes disease, but from outside the joint and indirectly via B lymphocytes and immunoglobulins. |
| Published Version: | doi:10.1186/ar73 |
| Other Sources: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC129991/pdf/ |
| Terms of Use: | This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA |
| Citable link to this page: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:5343539 |
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