MicroRNAs and Their Target Gene Networks in Breast Cancer

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MicroRNAs and Their Target Gene Networks in Breast Cancer

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Title: MicroRNAs and Their Target Gene Networks in Breast Cancer
Author: O'Day, Elizabeth; Lal, Ashish

Note: Order does not necessarily reflect citation order of authors.

Citation: O'Day, Elizabeth, and Ashish Lal. 2010. MicroRNAs and their target gene networks in breast cancer. Breast Cancer Research 12(2): 201.
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Abstract: MicroRNAs (miRNAs) are a major class of small endogenous RNA molecules that post-transcriptionally inhibit gene expression. Many miRNAs have been implicated in several human cancers, including breast cancer. Here we describe the association between altered miRNA signatures and breast cancer tumorigenesis and metastasis. The loss of several tumor suppressor miRNAs (miR-206, miR-17-5p, miR-125a, miR-125b, miR-200, let-7, miR-34 and miR-31) and the overexpression of certain oncogenic miRNAs (miR-21, miR-155, miR-10b, miR-373 and miR-520c) have been observed in many breast cancers. The gene networks orchestrated by these miRNAs are still largely unknown, although key targets have been identified that may contribute to the disease phenotype. Here we report how the observed perturbations in miRNA expression profiles may lead to disruption of key pathways involved in breast cancer.
Published Version: doi:10.1186/bcr2484
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2879559/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:5345645

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