Show simple item record

dc.contributor.authorO'Day, Elizabeth
dc.contributor.authorLal, Ashish
dc.date.accessioned2011-11-15T15:51:39Z
dc.date.issued2010
dc.identifier.citationO'Day, Elizabeth, and Ashish Lal. 2010. MicroRNAs and their target gene networks in breast cancer. Breast Cancer Research 12(2): 201.en_US
dc.identifier.issn1465-5411en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:5345645
dc.description.abstractMicroRNAs (miRNAs) are a major class of small endogenous RNA molecules that post-transcriptionally inhibit gene expression. Many miRNAs have been implicated in several human cancers, including breast cancer. Here we describe the association between altered miRNA signatures and breast cancer tumorigenesis and metastasis. The loss of several tumor suppressor miRNAs (miR-206, miR-17-5p, miR-125a, miR-125b, miR-200, let-7, miR-34 and miR-31) and the overexpression of certain oncogenic miRNAs (miR-21, miR-155, miR-10b, miR-373 and miR-520c) have been observed in many breast cancers. The gene networks orchestrated by these miRNAs are still largely unknown, although key targets have been identified that may contribute to the disease phenotype. Here we report how the observed perturbations in miRNA expression profiles may lead to disruption of key pathways involved in breast cancer.en_US
dc.language.isoen_USen_US
dc.publisherBioMed Centralen_US
dc.relation.isversionofdoi:10.1186/bcr2484en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2879559/pdf/en_US
dash.licenseLAA
dc.titleMicroRNAs and Their Target Gene Networks in Breast Canceren_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalBreast Cancer Research : BCRen_US
dash.depositing.authorLal, Ashish
dc.date.available2011-11-15T15:51:39Z
dash.affiliation.otherHMS^Pediatrics-Children's Hospitalen_US
dc.identifier.doi10.1186/bcr2484*
dash.contributor.affiliatedLal, Ashish


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record