Intraoperative Redosing of Cefazolin and Risk for Surgical Site Infection in Cardiac Surgery

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Intraoperative Redosing of Cefazolin and Risk for Surgical Site Infection in Cardiac Surgery

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Title: Intraoperative Redosing of Cefazolin and Risk for Surgical Site Infection in Cardiac Surgery
Author: Platt, Richard; Zanetti, Giorgio; Giardina, Richard

Note: Order does not necessarily reflect citation order of authors.

Citation: Zanetti, Giorgio, Richard Giardina, and Richard Platt. 2001. Intraoperative redosing of cefazolin and risk for surgical site infection in cardiac surgery. Emerging Infectious Diseases 7(5): 828-831.
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Abstract: Intraoperative redosing of prophylactic antibiotics is recommended for prolonged surgical procedures, although its efficacy has not been assessed. We retrospectively compared the risk of surgical site infections in 1,548 patients who underwent cardiac surgery lasting >240 min after preoperative administration of cefazolin prophylaxis. The overall risk of surgical site infection was similar among patients with (43 [9.4%] of 459) and without (101 [9.3%] of 1,089) intraoperative redosing (odds ratio [OR] 1.01, 95% confidence interval [CI] 0.70-1.47). However, redosing was beneficial in procedures lasting >400 min: infection occurred in 14 (7.7%) of 182 patients with redosing and in 32 (16.0%) of 200 patients without (adjusted OR 0.44, 95% CI 0.23-0.86). Intraoperative redosing of cefazolin was associated with a 16% reduction in the overall risk for surgical site infection after cardiac surgery, including procedures lasting <240 min.
Published Version: doi:10.3201/eid0705.010509
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2631868/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:5346775

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