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dc.contributor.authorBohland, Jason W.
dc.contributor.authorWu, Caizhi
dc.contributor.authorBarbas, Helen
dc.contributor.authorBokil, Hemant
dc.contributor.authorBota, Mihail
dc.contributor.authorCline, Hollis T.
dc.contributor.authorFreed, Peter J.
dc.contributor.authorGreenspan, Ralph J.
dc.contributor.authorHaber, Suzanne N.
dc.contributor.authorHawrylycz, Michael
dc.contributor.authorHilgetag, Claus C.
dc.contributor.authorJones, Allan
dc.contributor.authorKarten, Harvey J.
dc.contributor.authorKleinfeld, David
dc.contributor.authorKötter, Rolf
dc.contributor.authorLester, Henry A.
dc.contributor.authorLin, John M.
dc.contributor.authorMikula, Shawn
dc.contributor.authorPanksepp, Jaak
dc.contributor.authorPrice, Joseph L.
dc.contributor.authorSafdieh, Joseph
dc.contributor.authorSchiff, Nicholas D.
dc.contributor.authorStillman, Bruce W.
dc.contributor.authorSvoboda, Karel
dc.contributor.authorSwanson, Larry W.
dc.contributor.authorToga, Arthur W.
dc.contributor.authorVan Essen, David C.
dc.contributor.authorMitra, Partha P.
dc.contributor.authorSporns, Olaf
dc.contributor.authorBreiter, Hans Charles
dc.contributor.authorDoyle, John C.
dc.contributor.authorHerrera, Daniel Gustavo
dc.contributor.authorHuang, Z. Josh
dc.contributor.authorJones, Edward G.
dc.contributor.authorMensh, Brett Daren
dc.contributor.authorSaper, Clifford B.
dc.contributor.authorSchmahmann, Jeremy Dan
dc.contributor.authorWatson, James D.
dc.date.accessioned2011-11-16T18:01:58Z
dc.date.issued2009
dc.identifier.citationBohland, Jason W., Caizhi Wu, Helen Barbas, Hemant Bokil, Mihail Bota, Hans C. Breiter, Hollis T. Cline, and et al. 2009. A proposal for a coordinated effort for the determination of brainwide neuroanatomical connectivity in model organisms at a mesoscopic scale. PLoS Computational Biology 5(3): e1000334.en_US
dc.identifier.issn1553-734Xen_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:5346779
dc.description.abstractIn this era of complete genomes, our knowledge of neuroanatomical circuitry remains surprisingly sparse. Such knowledge is critical, however, for both basic and clinical research into brain function. Here we advocate for a concerted effort to fill this gap, through systematic, experimental mapping of neural circuits at a mesoscopic scale of resolution suitable for comprehensive, brainwide coverage, using injections of tracers or viral vectors. We detail the scientific and medical rationale and briefly review existing knowledge and experimental techniques. We define a set of desiderata, including brainwide coverage; validated and extensible experimental techniques suitable for standardization and automation; centralized, open-access data repository; compatibility with existing resources; and tractability with current informatics technology. We discuss a hypothetical but tractable plan for mouse, additional efforts for the macaque, and technique development for human. We estimate that the mouse connectivity project could be completed within five years with a comparatively modest budget.en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi://10.1371/journal.pcbi.1000334en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2655718/pdf/en_US
dash.licenseLAA
dc.subjectneuroscienceen_US
dc.titleA Proposal for a Coordinated Effort for the Determination of Brainwide Neuroanatomical Connectivity in Model Organisms at a Mesoscopic Scaleen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS Computational Biologyen_US
dash.depositing.authorSchmahmann, Jeremy Dan
dc.date.available2011-11-16T18:01:58Z
dash.affiliation.otherHMS^Psychiatry-Brigham and Women's Hospitalen_US
dc.identifier.doi10.1371/journal.pcbi.1000334*
dash.authorsorderedfalse
dash.contributor.affiliatedHerrera, Daniel Gustavo
dash.contributor.affiliatedMensh, Brett Daren
dash.contributor.affiliatedBreiter, Hans C.
dash.contributor.affiliatedSaper, Clifford
dash.contributor.affiliatedSchmahmann, Jeremy


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