Rb and Hematopoiesis: Stem Cells to Anemia

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Rb and Hematopoiesis: Stem Cells to Anemia

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Title: Rb and Hematopoiesis: Stem Cells to Anemia
Author: Walkley, Carl R; Sankaran, Vijay Ganesh; Orkin, Stuart Holland

Note: Order does not necessarily reflect citation order of authors.

Citation: Walkley, Carl R, Vijay G Sankaran, and Stuart H Orkin. 2008. Rb and hematopoiesis: Stem cells to anemia. Cell Division 3: 13.
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Abstract: The retinoblastoma protein, Rb, was one of the first tumor suppressor genes identified as a result of the familial syndrome retinoblastoma. In the period since its identification and cloning a large number of studies have described its role in various cellular processes. The application of conditional somatic mutation with lineage and temporally controlled gene deletion strategies, thus circumventing the lethality associated with germ-line deletion of Rb, have allowed for a reanalysis of the in vivo role of Rb. In the hematopoietic system, such approaches have led to new insights into stem cell biology and the role of the microenvironment in regulating hematopoietic stem cell fate. They have also clarified the role that Rb plays during erythropoiesis and defined a novel mechanism linking mitochondrial function to terminal cell cycle withdrawal. These studies have shed light on the in vivo role of Rb in the regulation of hematopoiesis and also prompt further analysis of the role that Rb plays in both the regulation of hematopoietic stem cells and the terminal differentiation of their progeny.
Published Version: doi://10.1186/1747-1028-3-13
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562376/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:5346782

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