A Genetic and Functional Relationship between T Cells and Cellular Proliferation in the Adult Hippocampus

DSpace/Manakin Repository

A Genetic and Functional Relationship between T Cells and Cellular Proliferation in the Adult Hippocampus

Citable link to this page

. . . . . .

Title: A Genetic and Functional Relationship between T Cells and Cellular Proliferation in the Adult Hippocampus
Author: Huang, Guo-Jen; Smith, Adrian L.; Gray, Daniel H.D.; Cosgrove, Cormac; Singer, Benjamin H.; Edwards, Andrew; Sim, Stuart; Parent, Jack M.; Johnsen, Alyssa; Mott, Richard; Klenerman, Paul; Flint, Jonathan; Mathis, Diane J.; Benoist, Christophe O.

Note: Order does not necessarily reflect citation order of authors.

Citation: Huang, Guo-Jen, Adrian L. Smith, Daniel H. D. Gray, Cormac Cosgrove, Benjamin H. Singer, Andrew Edwards, Stuart Sim, et al. 2010. A Genetic and Functional Relationship between T Cells and Cellular Proliferation in the Adult Hippocampus. PLoS Biology 8(12): e1000561.
Full Text & Related Files:
Abstract: Neurogenesis continues through the adult life of mice in the subgranular zone of the dentate gyrus in the hippocampus, but its function remains unclear. Measuring cellular proliferation in the hippocampus of 719 outbred heterogeneous stock mice revealed a highly significant correlation with the proportions of CD8+ versus CD4+ T lymphocyte subsets. This correlation reflected shared genetic loci, with the exception of the H-2Ea locus that had a dominant influence on T cell subsets but no impact on neurogenesis. Analysis of knockouts and repopulation of TCRa-deficient mice by subsets of T cells confirmed the influence of T cells on adult neurogenesis, indicating that CD4+ T cells or subpopulations thereof mediate the effect. Our results reveal an organismal impact, broader than hitherto suspected, of the natural genetic variation that controls T cell development and homeostasis.
Published Version: doi:10.1371/journal.pbio.1000561
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001898/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:5350538

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters