A Genetic and Functional Relationship between T Cells and Cellular Proliferation in the Adult Hippocampus

A Genetic and Functional Relationship between T Cells and Cellular Proliferation in the Adult Hippocampus

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A Genetic and Functional Relationship between T Cells and Cellular Proliferation in the Adult Hippocampus

dc.contributor.author	Huang, Guo-Jen
dc.contributor.author	Smith, Adrian L.
dc.contributor.author	Gray, Daniel H.D.
dc.contributor.author	Cosgrove, Cormac
dc.contributor.author	Singer, Benjamin H.
dc.contributor.author	Edwards, Andrew
dc.contributor.author	Sim, Stuart
dc.contributor.author	Parent, Jack M.
dc.contributor.author	Johnsen, Alyssa
dc.contributor.author	Mott, Richard
dc.contributor.author	Klenerman, Paul
dc.contributor.author	Flint, Jonathan
dc.contributor.author	Mathis, Diane J.
dc.contributor.author	Benoist, Christophe O.
dc.date.accessioned	2011-11-22T15:35:00Z
dc.date.issued	2010
dc.identifier.citation	Huang, Guo-Jen, Adrian L. Smith, Daniel H. D. Gray, Cormac Cosgrove, Benjamin H. Singer, Andrew Edwards, Stuart Sim, et al. 2010. A Genetic and Functional Relationship between T Cells and Cellular Proliferation in the Adult Hippocampus. PLoS Biology 8(12): e1000561.	en_US
dc.identifier.issn	1544-9173	en_US
dc.identifier.uri	http://nrs.harvard.edu/urn-3:HUL.InstRepos:5350538
dc.description.abstract	Neurogenesis continues through the adult life of mice in the subgranular zone of the dentate gyrus in the hippocampus, but its function remains unclear. Measuring cellular proliferation in the hippocampus of 719 outbred heterogeneous stock mice revealed a highly significant correlation with the proportions of CD8+ versus CD4+ T lymphocyte subsets. This correlation reflected shared genetic loci, with the exception of the H-2Ea locus that had a dominant influence on T cell subsets but no impact on neurogenesis. Analysis of knockouts and repopulation of TCRa-deficient mice by subsets of T cells confirmed the influence of T cells on adult neurogenesis, indicating that CD4+ T cells or subpopulations thereof mediate the effect. Our results reveal an organismal impact, broader than hitherto suspected, of the natural genetic variation that controls T cell development and homeostasis.	en_US
dc.language.iso	en_US	en_US
dc.publisher	Public Library of Science	en_US
dc.relation.isversionof	doi:10.1371/journal.pbio.1000561	en_US
dc.relation.hasversion	http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001898/pdf/	en_US
dash.license	LAA
dc.subject	genetics and genomics	en_US
dc.subject	complex traits	en_US
dc.subject	gene function	en_US
dc.subject	genetics of the immune system	en_US
dc.subject	neuroscience	en_US
dc.subject	animal cognition	en_US
dc.subject	experimental psychology	en_US
dc.title	A Genetic and Functional Relationship between T Cells and Cellular Proliferation in the Adult Hippocampus	en_US
dc.type	Journal Article	en_US
dc.description.version	Version of Record	en_US
dc.relation.journal	PLoS Biology	en_US
dash.depositing.author	Mathis, Diane J.
dc.date.available	2011-11-22T15:35:00Z
dash.affiliation.other	HMS^Pathology	en_US
dash.affiliation.other	HMS^Pathology	en_US