A Genetic and Functional Relationship between T Cells and Cellular Proliferation in the Adult Hippocampus

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A Genetic and Functional Relationship between T Cells and Cellular Proliferation in the Adult Hippocampus

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dc.contributor.author Huang, Guo-Jen
dc.contributor.author Smith, Adrian L.
dc.contributor.author Gray, Daniel H.D.
dc.contributor.author Cosgrove, Cormac
dc.contributor.author Singer, Benjamin H.
dc.contributor.author Edwards, Andrew
dc.contributor.author Sim, Stuart
dc.contributor.author Parent, Jack M.
dc.contributor.author Johnsen, Alyssa
dc.contributor.author Mott, Richard
dc.contributor.author Klenerman, Paul
dc.contributor.author Flint, Jonathan
dc.contributor.author Mathis, Diane J.
dc.contributor.author Benoist, Christophe O.
dc.date.accessioned 2011-11-22T15:35:00Z
dc.date.issued 2010
dc.identifier.citation Huang, Guo-Jen, Adrian L. Smith, Daniel H. D. Gray, Cormac Cosgrove, Benjamin H. Singer, Andrew Edwards, Stuart Sim, et al. 2010. A Genetic and Functional Relationship between T Cells and Cellular Proliferation in the Adult Hippocampus. PLoS Biology 8(12): e1000561. en_US
dc.identifier.issn 1544-9173 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:5350538
dc.description.abstract Neurogenesis continues through the adult life of mice in the subgranular zone of the dentate gyrus in the hippocampus, but its function remains unclear. Measuring cellular proliferation in the hippocampus of 719 outbred heterogeneous stock mice revealed a highly significant correlation with the proportions of CD8+ versus CD4+ T lymphocyte subsets. This correlation reflected shared genetic loci, with the exception of the H-2Ea locus that had a dominant influence on T cell subsets but no impact on neurogenesis. Analysis of knockouts and repopulation of TCRa-deficient mice by subsets of T cells confirmed the influence of T cells on adult neurogenesis, indicating that CD4+ T cells or subpopulations thereof mediate the effect. Our results reveal an organismal impact, broader than hitherto suspected, of the natural genetic variation that controls T cell development and homeostasis. en_US
dc.language.iso en_US en_US
dc.publisher Public Library of Science en_US
dc.relation.isversionof doi:10.1371/journal.pbio.1000561 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001898/pdf/ en_US
dash.license LAA
dc.subject genetics and genomics en_US
dc.subject complex traits en_US
dc.subject gene function en_US
dc.subject genetics of the immune system en_US
dc.subject neuroscience en_US
dc.subject animal cognition en_US
dc.subject experimental psychology en_US
dc.title A Genetic and Functional Relationship between T Cells and Cellular Proliferation in the Adult Hippocampus en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal PLoS Biology en_US
dash.depositing.author Mathis, Diane J.
dc.date.available 2011-11-22T15:35:00Z
dash.affiliation.other HMS^Pathology en_US
dash.affiliation.other HMS^Pathology en_US

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