Pathogenicity of a Disease-associated Human IL-4 Receptor Allele in Experimental Asthma

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Pathogenicity of a Disease-associated Human IL-4 Receptor Allele in Experimental Asthma

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Title: Pathogenicity of a Disease-associated Human IL-4 Receptor Allele in Experimental Asthma
Author: Tachdjian, Raffi; Al Khatib, Shadi; Bryce, Paul J.; Kim, Hong S.; Blaeser, Frank; O'Connor, Brian D.; Rzymkiewicz, Danuta; Holtzman, Michael J.; Hershey, Gurjit K.; Garn, Holger; Harb, Hani; Chatila, Talal A.; Mathias, Clinton B.; Chen, Andrew; Renz, Harald; Oettgen, Hans Christoph

Note: Order does not necessarily reflect citation order of authors.

Citation: Tachdjian, Raffi, Clinton Mathias, Shadi Al Khatib, Paul J. Bryce, Hong S. Kim, Frank Blaeser, Brian D. O'Connor, et al. 2009. Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma. The Journal of Experimental Medicine 206(10): 2191-2204.
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Abstract: Polymorphisms in the interleukin-4 receptor α chain (IL-4Rα) have been linked to asthma incidence and severity, but a causal relationship has remained uncertain. In particular, a glutamine to arginine substitution at position 576 (Q576R) of IL-4Rα has been associated with severe asthma, especially in African Americans. We show that mice carrying the Q576R polymorphism exhibited intense allergen-induced airway inflammation and remodeling. The Q576R polymorphism did not affect proximal signal transducer and activator of transcription (STAT) 6 activation, but synergized with STAT6 in a gene target– and tissue-specific manner to mediate heightened expression of a subset of IL-4– and IL-13–responsive genes involved in allergic inflammation. Our findings indicate that the Q576R polymorphism directly promotes asthma in carrier populations by selectively augmenting IL-4Rα–dependent signaling.
Published Version: doi://10.1084/jem.20091480
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757875/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:5350698

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