The Impact of Different Antibiotic Regimens on the Emergence of Antimicrobial-Resistant Bacteria

DSpace/Manakin Repository

The Impact of Different Antibiotic Regimens on the Emergence of Antimicrobial-Resistant Bacteria

Citable link to this page

. . . . . .

Title: The Impact of Different Antibiotic Regimens on the Emergence of Antimicrobial-Resistant Bacteria
Author: Dupont-Rouzeyrol, Myrielle; Magal, Pierre; Olivier, Damien; Ruan, Shigui; D'Agata, Erika Maria Concetta

Note: Order does not necessarily reflect citation order of authors.

Citation: D'Agata, Erika M. C., Myrielle Dupont-Rouzeyrol, Pierre Magal, Damien Olivier, and Shigui Ruan. 2008. The Impact of Different Antibiotic Regimens on the Emergence of Antimicrobial-Resistant Bacteria. PLoS ONE 3(12): e4036.
Full Text & Related Files:
Abstract: Backgroud: The emergence and ongoing spread of antimicrobial-resistant bacteria is a major public health threat. Infections caused by antimicrobial-resistant bacteria are associated with substantially higher rates of morbidity and mortality compared to infections caused by antimicrobial-susceptible bacteria. The emergence and spread of these bacteria is complex and requires incorporating numerous interrelated factors which clinical studies cannot adequately address. Methods/Principal Findings: A model is created which incorporates several key factors contributing to the emergence and spread of resistant bacteria including the effects of the immune system, acquisition of resistance genes and antimicrobial exposure. The model identifies key strategies which would limit the emergence of antimicrobial-resistant bacterial strains. Specifically, the simulations show that early initiation of antimicrobial therapy and combination therapy with two antibiotics prevents the emergence of resistant bacteria, whereas shorter courses of therapy and sequential administration of antibiotics promote the emergence of resistant strains. Conclusions/Significance: The principal findings suggest that (i) shorter lengths of antibiotic therapy and early interruption of antibiotic therapy provide an advantage for the resistant strains, (ii) combination therapy with two antibiotics prevents the emergence of resistance strains in contrast to sequential antibiotic therapy, and (iii) early initiation of antibiotics is among the most important factors preventing the emergence of resistant strains. These findings provide new insights into strategies aimed at optimizing the administration of antimicrobials for the treatment of infections and the prevention of the emergence of antimicrobial resistance.
Published Version: doi:10.1371/journal.pone.0004036
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2603320/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:5355101

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters