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dc.contributor.authorUdayakumar, Durga
dc.contributor.authorTsao, Hensin
dc.date.accessioned2011-11-29T07:26:35Z
dc.date.issued2009
dc.identifier.citationUdayakumar, Durga, and Hensin Tsao. 2009. Moderate- to low-risk variant alleles of cutaneous malignancies and nevi: lessons from genome-wide association studies. Genome Medicine 1, no. 10: 95.en_US
dc.identifier.issn1756-994Xen_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:5355109
dc.description.abstractCutaneous malignancies, especially malignant melanoma, exhibit great genetic heterogeneity. As a result, some individuals and families have particularly increased risk due to genetic predisposition to the disease. The susceptibility alleles range from rarely occurring, heritable, high-risk variants to ubiquitously occurring low-risk variants. Although until now the focus has been mostly towards the familial high-risk genes, the development of genome-wide association studies has uncovered a number of moderate- to low-risk predisposition alleles. The ability to specifically identify genetic variation associated with visible pigmentation traits and disease risk has provided a much richer view of the genetics of cutaneous malignancies. In this review, we provide an update on the recently identified risk loci. Existing clinical data, combined with vast genome information, will provide a better understanding of the biology of disease, and increased accuracy in risk prediction.en_US
dc.language.isoen_USen_US
dc.publisherBioMed Centralen_US
dc.relation.isversionofdoi://10.1186/gm95en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784308/pdf/en_US
dc.relation.hasversionhttp://genomemedicine.com/content/1/10/95en_US
dash.licenseLAA
dc.titleModerate- to Low-Risk Variant Alleles of Cutaneous Malignancies and Nevi: Lessons from Genome-Wide Association Studiesen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalGenome Medicineen_US
dash.depositing.authorTsao, Hensin
dc.date.available2011-11-29T07:26:35Z
dash.affiliation.otherHMS^Health Sciences and Technologyen_US
dash.affiliation.otherHMS^Dermatology-Massachusetts General Hospitalen_US
dc.identifier.doi10.1186/gm95*
dash.contributor.affiliatedUdayakumar, Durga
dash.contributor.affiliatedTsao, Hensin


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