Bioluminescence Imaging Reveals Inhibition of Tumor Cell Proliferation by Alzheimer's Amyloid β Protein

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Bioluminescence Imaging Reveals Inhibition of Tumor Cell Proliferation by Alzheimer's Amyloid β Protein

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Title: Bioluminescence Imaging Reveals Inhibition of Tumor Cell Proliferation by Alzheimer's Amyloid β Protein
Author: Cui, Kemi; O'Brien, Megan; Wong, Kelvin K; Kesari, Santosh; Wong, Stephen TC; Zhao, Hong; Zhu, Jinmin; Xu, Xiaoyin; Xia, Weiming

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Citation: Zhao, Hong, Jinmin Zhu, Kemi Cui, Xiaoyin Xu, Megan O'Brien, Kelvin K. Wong, Santosh Kesari, Weiming Xia, and Stephen T.C. Wong. 2009. Bioluminescence imaging reveals inhibition of tumor cell proliferation by Alzheimer's amyloid β protein. Cancer Cell International 9: 15.
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Abstract: Background: Cancer and Alzheimer's disease (AD) are two seemingly distinct diseases and rarely occur simultaneously in patients. To explore molecular determinants differentiating pathogenic routes towards AD or cancer, we investigate the role of amyloid β protein (Aβ) on multiple tumor cell lines that are stably expressing luciferase (human glioblastoma U87; human breast adenocarcinoma MDA-MB231; and mouse melanoma B16F). Results: Quantification of the photons emitted from the MDA-MB231 or B16F cells revealed a significant inhibition of cell proliferation by the conditioning media (CM) derived from amyloid precursor protein (APP) over-expressing cells. The inhibition of U87 cells was observed only after the media was conditioned for longer than 2 days with APP over-expressing cells. Conclusion: Our results suggest that Aβ plays an inhibitory role in tumor cell proliferation; this effect could depend on the type of tumor cells and amount of Aβ.
Published Version: doi://10.1186/1475-2867-9-15
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701410/pdf/
http://www.cancerci.com/content/9/1/15
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:5355295

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