Bioluminescence Imaging Reveals Inhibition of Tumor Cell Proliferation by Alzheimer's Amyloid β Protein

DSpace/Manakin Repository

Bioluminescence Imaging Reveals Inhibition of Tumor Cell Proliferation by Alzheimer's Amyloid β Protein

Show simple item record

dc.contributor.author Cui, Kemi
dc.contributor.author O'Brien, Megan
dc.contributor.author Wong, Kelvin K
dc.contributor.author Kesari, Santosh
dc.contributor.author Wong, Stephen TC
dc.contributor.author Zhao, Hong
dc.contributor.author Zhu, Jinmin
dc.contributor.author Xu, Xiaoyin
dc.contributor.author Xia, Weiming
dc.date.accessioned 2011-11-29T15:46:37Z
dc.date.issued 2009
dc.identifier.citation Zhao, Hong, Jinmin Zhu, Kemi Cui, Xiaoyin Xu, Megan O'Brien, Kelvin K. Wong, Santosh Kesari, Weiming Xia, and Stephen T.C. Wong. 2009. Bioluminescence imaging reveals inhibition of tumor cell proliferation by Alzheimer's amyloid β protein. Cancer Cell International 9: 15. en_US
dc.identifier.issn 1475-2867 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:5355295
dc.description.abstract Background: Cancer and Alzheimer's disease (AD) are two seemingly distinct diseases and rarely occur simultaneously in patients. To explore molecular determinants differentiating pathogenic routes towards AD or cancer, we investigate the role of amyloid β protein (Aβ) on multiple tumor cell lines that are stably expressing luciferase (human glioblastoma U87; human breast adenocarcinoma MDA-MB231; and mouse melanoma B16F). Results: Quantification of the photons emitted from the MDA-MB231 or B16F cells revealed a significant inhibition of cell proliferation by the conditioning media (CM) derived from amyloid precursor protein (APP) over-expressing cells. The inhibition of U87 cells was observed only after the media was conditioned for longer than 2 days with APP over-expressing cells. Conclusion: Our results suggest that Aβ plays an inhibitory role in tumor cell proliferation; this effect could depend on the type of tumor cells and amount of Aβ. en_US
dc.language.iso en_US en_US
dc.publisher BioMed Central en_US
dc.relation.isversionof doi://10.1186/1475-2867-9-15 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701410/pdf/ en_US
dc.relation.hasversion http://www.cancerci.com/content/9/1/15 en_US
dash.license LAA
dc.title Bioluminescence Imaging Reveals Inhibition of Tumor Cell Proliferation by Alzheimer's Amyloid β Protein en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Cancer Cell International en_US
dash.depositing.author Xia, Weiming
dc.date.available 2011-11-29T15:46:37Z
dash.affiliation.other HMS^Neurology-Massachusetts General Hospital en_US
dash.affiliation.other HMS^Radiology-Brigham and Women's Hospital en_US
dash.affiliation.other HMS^Neurology-Brigham and Women's Hospital en_US

Files in this item

Files Size Format View
2701410.pdf 1.061Mb PDF View/Open

This item appears in the following Collection(s)

Show simple item record

 
 

Search DASH


Advanced Search
 
 

Submitters