Bioluminescence Imaging Reveals Inhibition of Tumor Cell Proliferation by Alzheimer's Amyloid β Protein

Bioluminescence Imaging Reveals Inhibition of Tumor Cell Proliferation by Alzheimer's Amyloid β Protein

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Bioluminescence Imaging Reveals Inhibition of Tumor Cell Proliferation by Alzheimer's Amyloid β Protein

dc.contributor.author	Cui, Kemi
dc.contributor.author	O'Brien, Megan
dc.contributor.author	Wong, Kelvin K
dc.contributor.author	Kesari, Santosh
dc.contributor.author	Wong, Stephen TC
dc.contributor.author	Zhao, Hong
dc.contributor.author	Zhu, Jinmin
dc.contributor.author	Xu, Xiaoyin
dc.contributor.author	Xia, Weiming
dc.date.accessioned	2011-11-29T15:46:37Z
dc.date.issued	2009
dc.identifier.citation	Zhao, Hong, Jinmin Zhu, Kemi Cui, Xiaoyin Xu, Megan O'Brien, Kelvin K. Wong, Santosh Kesari, Weiming Xia, and Stephen T.C. Wong. 2009. Bioluminescence imaging reveals inhibition of tumor cell proliferation by Alzheimer's amyloid β protein. Cancer Cell International 9: 15.	en_US
dc.identifier.issn	1475-2867	en_US
dc.identifier.uri	http://nrs.harvard.edu/urn-3:HUL.InstRepos:5355295
dc.description.abstract	Background: Cancer and Alzheimer's disease (AD) are two seemingly distinct diseases and rarely occur simultaneously in patients. To explore molecular determinants differentiating pathogenic routes towards AD or cancer, we investigate the role of amyloid β protein (Aβ) on multiple tumor cell lines that are stably expressing luciferase (human glioblastoma U87; human breast adenocarcinoma MDA-MB231; and mouse melanoma B16F). Results: Quantification of the photons emitted from the MDA-MB231 or B16F cells revealed a significant inhibition of cell proliferation by the conditioning media (CM) derived from amyloid precursor protein (APP) over-expressing cells. The inhibition of U87 cells was observed only after the media was conditioned for longer than 2 days with APP over-expressing cells. Conclusion: Our results suggest that Aβ plays an inhibitory role in tumor cell proliferation; this effect could depend on the type of tumor cells and amount of Aβ.	en_US
dc.language.iso	en_US	en_US
dc.publisher	BioMed Central	en_US
dc.relation.isversionof	doi://10.1186/1475-2867-9-15	en_US
dc.relation.hasversion	http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701410/pdf/	en_US
dc.relation.hasversion	http://www.cancerci.com/content/9/1/15	en_US
dash.license	LAA
dc.title	Bioluminescence Imaging Reveals Inhibition of Tumor Cell Proliferation by Alzheimer's Amyloid β Protein	en_US
dc.type	Journal Article	en_US
dc.description.version	Version of Record	en_US
dc.relation.journal	Cancer Cell International	en_US
dash.depositing.author	Xia, Weiming
dc.date.available	2011-11-29T15:46:37Z
dash.affiliation.other	HMS^Neurology-Massachusetts General Hospital	en_US
dash.affiliation.other	HMS^Radiology-Brigham and Women's Hospital	en_US
dash.affiliation.other	HMS^Neurology-Brigham and Women's Hospital	en_US