A Quantitative Systems View of the Spindle Assembly Checkpoint

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A Quantitative Systems View of the Spindle Assembly Checkpoint

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dc.contributor.author Ciliberto, Andrea
dc.contributor.author Shah, Jagesh V.
dc.date.accessioned 2011-11-29T16:26:53Z
dc.date.issued 2009
dc.identifier.citation Ciliberto, Andrea, and Jagesh V. Shah. 2009. A quantitative systems view of the spindle assembly checkpoint. The EMBO Journal 28(15): 2162-2173. en_US
dc.identifier.issn 0261-4189 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:5355309
dc.description.abstract The idle assembly checkpoint acts to delay chromosome segregation until all duplicated sister chromatids are captured by the mitotic spindle. This pathway ensures that each daughter cell receives a complete copy of the genome. The high fidelity and robustness of this process have made it a subject of intense study in both the experimental and computational realms. A significant number of checkpoint proteins have been identified but how they orchestrate the communication between local spindle attachment and global cytoplasmic signalling to delay segregation is not yet understood. Here, we propose a systems view of the spindle assembly checkpoint to focus attention on the key regulators of the dynamics of this pathway. These regulators in turn have been the subject of detailed cellular measurements and computational modelling to connect molecular function to the dynamics of spindle assembly checkpoint signalling. A review of these efforts reveals the insights provided by such approaches and underscores the need for further interdisciplinary studies to reveal in full the quantitative underpinnings of this cellular control pathway. en_US
dc.language.iso en_US en_US
dc.publisher Nature Publishing Group en_US
dc.relation.isversionof doi:10.1038/emboj.2009.186 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722251/pdf/ en_US
dash.license LAA
dc.subject kinetochore en_US
dc.subject mathematical modelling en_US
dc.subject quantitative biology en_US
dc.subject spindle assembly checkpoint en_US
dc.subject systems biology en_US
dc.title A Quantitative Systems View of the Spindle Assembly Checkpoint en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal The EMBO Journal en_US
dash.depositing.author Shah, Jagesh V.
dc.date.available 2011-11-29T16:26:53Z
dash.affiliation.other HMS^Health Sciences and Technology en_US
dash.affiliation.other HMS^Medicine-Brigham and Women's Hospital en_US
dash.affiliation.other HMS^Systems Biology en_US

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