Genital Tract Sequestration of SIV following Acute Infection

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Genital Tract Sequestration of SIV following Acute Infection

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Title: Genital Tract Sequestration of SIV following Acute Infection
Author: Whitney, James B.; Hraber, Peter T.; Luedemann, Corinne; Giorgi, Elena E.; Daniels, Marcus G.; Bhattacharya, Tanmoy; Rao, Srinivas S.; Mascola, John R.; Nabel, Gary J.; Korber, Bette T.; Letvin, Norman Lee

Note: Order does not necessarily reflect citation order of authors.

Citation: Whitney, James B., Peter T. Hraber, Corinne Luedemann, Elena E. Giorgi, Marcus G. Daniels, Tanmoy Bhattacharya, Srinivas S. Rao, et al. 2011. Genital tract sequestration of SIV following acute infection. PLoS Pathogens 7(2): e1001293.
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Abstract: We characterized the evolution of simian immunodeficiency virus (SIV) in the male genital tract by examining blood- and semen-associated virus from experimentally and sham vaccinated rhesus monkeys during primary infection. At the time of peak virus replication, SIV sequences were intermixed between the blood and semen supporting a scenario of high-level virus "spillover" into the male genital tract. However, at the time of virus set point, compartmentalization was apparent in 4 of 7 evaluated monkeys, likely as a consequence of restricted virus gene flow between anatomic compartments after the resolution of primary viremia. These findings suggest that SIV replication in the male genital tract evolves to compartmentalization after peak viremia resolves.
Published Version: doi:10.1371/journal.ppat.1001293
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040679/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:5358881

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