High-Density Genomewide Linkage Analysis of Exceptional Human Longevity Identifies Multiple Novel Loci
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High-Density Genomewide Linkage Analysis of Exceptional Human Longevity Identifies Multiple Novel Loci
| Title: | High-Density Genomewide Linkage Analysis of Exceptional Human Longevity Identifies Multiple Novel Loci |
| Author: |
Boyden, Steven Edward; Kunkel, Louis Martens
Note: Order does not necessarily reflect citation order of authors. |
| Citation: | Boyden, Steven E., and Louis M. Kunkel. 2010. High-density genomewide linkage analysis of exceptional human longevity identifies multiple novel loci. PLoS ONE 5(8): e12432. |
| Full Text & Related Files: |
2930849.pdf (490.6Kb; PDF) 
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| Abstract: | Background: Human lifespan is approximately 25% heritable, and genetic factors may be particularly important for achieving exceptional longevity. Accordingly, siblings of centenarians have a dramatically higher probability of reaching extreme old age than the general population. Methodology/Principal Findings To map the loci conferring a survival advantage, we performed the second genomewide linkage scan on human longevity and the first using a high-density marker panel of single nucleotide polymorphisms. By systematically testing a range of minimum age cutoffs in 279 families with multiple long-lived siblings, we identified a locus on chromosome 3p24-22 with a genomewide significant allele-sharing LOD score of 4.02 (empirical P = 0.037) and a locus on chromosome 9q31-34 with a highly suggestive LOD score of 3.89 (empirical P = 0.054). The empirical P value for the combined result was 0.002. A third novel locus with a LOD score of 4.05 on chromosome 12q24 was detected in a subset of the data, and we also obtained modest evidence for a previously reported interval on chromosome 4q22-25. Conclusions/Significance Our linkage data should facilitate the discovery of both common and rare variants that determine genetic variability in lifespan. |
| Published Version: | doi://10.1371/journal.pone.0012432 |
| Other Sources: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2930849/pdf/ |
| Terms of Use: | This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA |
| Citable link to this page: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:5361101 |
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