Selenoproteins Regulate Macrophage Invasiveness and Extracellular Matrix-related Gene Expression

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Selenoproteins Regulate Macrophage Invasiveness and Extracellular Matrix-related Gene Expression

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dc.contributor.author Carlson, Bradley A.
dc.contributor.author Yoo, Min-Hyuk
dc.contributor.author Sano, Yasuyo
dc.contributor.author Sengupta, Aniruddha
dc.contributor.author Kim, Jin Young
dc.contributor.author Irons, Robert
dc.contributor.author Gladyshev, Vadim
dc.contributor.author Hatfield, Dolph L.
dc.contributor.author Park, Jin Mo
dc.date.accessioned 2011-12-06T20:07:05Z
dc.date.issued 2009
dc.identifier.citation Carlson, Bradley A, Min-Hyuk Yoo, Yasuyo Sano, Aniruddha Sengupta, Jin Young Kim, Robert Irons, Vadim N Gladyshev, Dolph L Hatfield, and Jin Mo Park. 2009. Selenoproteins regulate macrophage invasiveness and extracellular matrix-related gene expression. BMC Immunology 10: 57. en_US
dc.identifier.issn 1471-2172 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:5361169
dc.description.abstract Background: Selenium, a micronutrient whose deficiency in diet causes immune dysfunction and inflammatory disorders, is thought to exert its physiological effects mostly in the form of selenium-containing proteins (selenoproteins). Incorporation of selenium into the amino acid selenocysteine (Sec), and subsequently into selenoproteins is mediated by \(Sec\) \(tRNA^{[Ser]Sec}\). Results: To define macrophage-specific selenoprotein functions, we generated mice with the \(Sec\) \(tRNA^{[Ser]Sec}\) gene specifically deleted in myeloid cells. These mutant mice were devoid of the "selenoproteome" in macrophages, yet exhibited largely normal inflammatory responses. However, selenoprotein deficiency led to aberrant expression of extracellular matrix-related genes, and diminished migration of macrophages in a protein gel matrix. Conclusion: Selenium status may affect immune defense and tissue homeostasis through its effect on selenoprotein expression and the trafficking of tissue macrophages. en_US
dc.language.iso en_US en_US
dc.publisher BioMed Central en_US
dc.relation.isversionof doi://10.1186/1471-2172-10-57 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774298/pdf/ en_US
dash.license LAA
dc.subject selenocysteine en_US
dc.subject transfer-RNA en_US
dc.subject signal-transduction en_US
dc.subject innate immunity en_US
dc.subject kappa-B en_US
dc.subject activation en_US
dc.subject selenium en_US
dc.subject mice en_US
dc.subject inhibition en_US
dc.subject TRSP en_US
dc.title Selenoproteins Regulate Macrophage Invasiveness and Extracellular Matrix-related Gene Expression en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal BMC Immunology en_US
dash.depositing.author Park, Jin Mo
dc.date.available 2011-12-06T20:07:05Z
dash.affiliation.other HMS^Dermatology-Massachusetts General Hospital en_US

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