Selenoproteins Regulate Macrophage Invasiveness and Extracellular Matrix-related Gene Expression

Selenoproteins Regulate Macrophage Invasiveness and Extracellular Matrix-related Gene Expression

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Selenoproteins Regulate Macrophage Invasiveness and Extracellular Matrix-related Gene Expression

dc.contributor.author	Carlson, Bradley A.
dc.contributor.author	Yoo, Min-Hyuk
dc.contributor.author	Sano, Yasuyo
dc.contributor.author	Sengupta, Aniruddha
dc.contributor.author	Kim, Jin Young
dc.contributor.author	Irons, Robert
dc.contributor.author	Gladyshev, Vadim
dc.contributor.author	Hatfield, Dolph L.
dc.contributor.author	Park, Jin Mo
dc.date.accessioned	2011-12-06T20:07:05Z
dc.date.issued	2009
dc.identifier.citation	Carlson, Bradley A, Min-Hyuk Yoo, Yasuyo Sano, Aniruddha Sengupta, Jin Young Kim, Robert Irons, Vadim N Gladyshev, Dolph L Hatfield, and Jin Mo Park. 2009. Selenoproteins regulate macrophage invasiveness and extracellular matrix-related gene expression. BMC Immunology 10: 57.	en_US
dc.identifier.issn	1471-2172	en_US
dc.identifier.uri	http://nrs.harvard.edu/urn-3:HUL.InstRepos:5361169
dc.description.abstract	Background: Selenium, a micronutrient whose deficiency in diet causes immune dysfunction and inflammatory disorders, is thought to exert its physiological effects mostly in the form of selenium-containing proteins (selenoproteins). Incorporation of selenium into the amino acid selenocysteine (Sec), and subsequently into selenoproteins is mediated by \(Sec\) \(tRNA^{[Ser]Sec}\). Results: To define macrophage-specific selenoprotein functions, we generated mice with the \(Sec\) \(tRNA^{[Ser]Sec}\) gene specifically deleted in myeloid cells. These mutant mice were devoid of the "selenoproteome" in macrophages, yet exhibited largely normal inflammatory responses. However, selenoprotein deficiency led to aberrant expression of extracellular matrix-related genes, and diminished migration of macrophages in a protein gel matrix. Conclusion: Selenium status may affect immune defense and tissue homeostasis through its effect on selenoprotein expression and the trafficking of tissue macrophages.	en_US
dc.language.iso	en_US	en_US
dc.publisher	BioMed Central	en_US
dc.relation.isversionof	doi://10.1186/1471-2172-10-57	en_US
dc.relation.hasversion	http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774298/pdf/	en_US
dash.license	LAA
dc.subject	selenocysteine	en_US
dc.subject	transfer-RNA	en_US
dc.subject	signal-transduction	en_US
dc.subject	innate immunity	en_US
dc.subject	kappa-B	en_US
dc.subject	activation	en_US
dc.subject	selenium	en_US
dc.subject	mice	en_US
dc.subject	inhibition	en_US
dc.subject	TRSP	en_US
dc.title	Selenoproteins Regulate Macrophage Invasiveness and Extracellular Matrix-related Gene Expression	en_US
dc.type	Journal Article	en_US
dc.description.version	Version of Record	en_US
dc.relation.journal	BMC Immunology	en_US
dash.depositing.author	Park, Jin Mo
dc.date.available	2011-12-06T20:07:05Z
dash.affiliation.other	HMS^Dermatology-Massachusetts General Hospital	en_US