Scaling Behavior of Human Locomotor Activity Amplitude: Association with Bipolar Disorder

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Scaling Behavior of Human Locomotor Activity Amplitude: Association with Bipolar Disorder

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Title: Scaling Behavior of Human Locomotor Activity Amplitude: Association with Bipolar Disorder
Author: Indic, Premananda; Salvatore, Paola; Maggini, Carlo; Ghidini, Stefano; Ferraro, Gabriella; Baldessarini, Ross John; Murray, Greg

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Citation: Indic, Premananda, Paola Salvatore, Carlo Maggini, Stefano Ghidini, Gabriella Ferraro, Ross J. Baldessarini, and Greg Murray. 2011. Scaling behavior of human locomotor activity amplitude: association with bipolar disorder. PLoS ONE 6(5): e20650.
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Abstract: Scale invariance is a feature of complex biological systems, and abnormality of multi-scale behaviour may serve as an indicator of pathology. The hypothalamic suprachiasmatic nucleus (SCN) is a major node in central neural networks responsible for regulating multi-scale behaviour in measures of human locomotor activity. SCN also is implicated in the pathophysiology of bipolar disorder (BD) or manic-depressive illness, a severe, episodic disorder of mood, cognition and behaviour. Here, we investigated scaling behaviour in actigraphically recorded human motility data for potential indicators of BD, particularly its manic phase. A proposed index of scaling behaviour (Vulnerability Index [VI]) derived from such data distinguished between: [i] healthy subjects at high versus low risk of mood disorders; [ii] currently clinically stable BD patients versus matched controls; and [iii] among clinical states in BD patients.
Published Version: doi:10.1371/journal.pone.0020650
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105113/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:5978615

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