Scaling Behavior of Human Locomotor Activity Amplitude: Association with Bipolar Disorder

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Scaling Behavior of Human Locomotor Activity Amplitude: Association with Bipolar Disorder

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dc.contributor.author Indic, Premananda
dc.contributor.author Salvatore, Paola
dc.contributor.author Maggini, Carlo
dc.contributor.author Ghidini, Stefano
dc.contributor.author Ferraro, Gabriella
dc.contributor.author Baldessarini, Ross John
dc.contributor.author Murray, Greg
dc.date.accessioned 2011-12-23T01:32:00Z
dc.date.issued 2011
dc.identifier.citation Indic, Premananda, Paola Salvatore, Carlo Maggini, Stefano Ghidini, Gabriella Ferraro, Ross J. Baldessarini, and Greg Murray. 2011. Scaling behavior of human locomotor activity amplitude: association with bipolar disorder. PLoS ONE 6(5): e20650. en_US
dc.identifier.issn 1932-6203 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:5978615
dc.description.abstract Scale invariance is a feature of complex biological systems, and abnormality of multi-scale behaviour may serve as an indicator of pathology. The hypothalamic suprachiasmatic nucleus (SCN) is a major node in central neural networks responsible for regulating multi-scale behaviour in measures of human locomotor activity. SCN also is implicated in the pathophysiology of bipolar disorder (BD) or manic-depressive illness, a severe, episodic disorder of mood, cognition and behaviour. Here, we investigated scaling behaviour in actigraphically recorded human motility data for potential indicators of BD, particularly its manic phase. A proposed index of scaling behaviour (Vulnerability Index [VI]) derived from such data distinguished between: [i] healthy subjects at high versus low risk of mood disorders; [ii] currently clinically stable BD patients versus matched controls; and [iii] among clinical states in BD patients. en_US
dc.language.iso en_US en_US
dc.publisher Public Library of Science en_US
dc.relation.isversionof doi:10.1371/journal.pone.0020650 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105113/pdf/ en_US
dash.license LAA
dc.subject biology en_US
dc.subject neuroscience en_US
dc.subject cognitive neuroscience en_US
dc.subject cognition en_US
dc.subject behavioral neuroscience en_US
dc.subject mathematics en_US
dc.subject nonlinear dynamics en_US
dc.subject medicine en_US
dc.subject mental health en_US
dc.subject psychiatry en_US
dc.subject mood disorders en_US
dc.subject neuropsychiatric disorders en_US
dc.subject psychology en_US
dc.subject behavior en_US
dc.subject physics en_US
dc.subject interdisciplinary physics en_US
dc.subject social and behavorial sciences en_US
dc.title Scaling Behavior of Human Locomotor Activity Amplitude: Association with Bipolar Disorder en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal PLoS ONE en_US
dash.depositing.author Baldessarini, Ross John
dc.date.available 2011-12-23T01:32:00Z
dash.affiliation.other 100168 en_US
dash.affiliation.other 100168 en_US

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