Single Nucleotide Polymorphisms and Breast Cancer: Not Yet a Success Story

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Single Nucleotide Polymorphisms and Breast Cancer: Not Yet a Success Story

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Title: Single Nucleotide Polymorphisms and Breast Cancer: Not Yet a Success Story
Author: Tamimi, Rulla May
Citation: Tamimi, Rulla M. 2006. Single nucleotide polymorphisms and breast cancer: not yet a success story. Breast Cancer Research 8(4): 108.
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Abstract: Numerous studies have examined low penetrance susceptibility polymorphisms in candidate genes, with some reporting significant findings. However, for the most part these associations could not be replicated in subsequent studies, suggesting that the original observations were due to chance. The failure to identify meaningful common genetic variation in relation to breast cancer should give us pause for thought and make us reconsider our current research strategies. The most recent directions of pooling samples to increase statistical power and pursuing whole genome screens may overcome some obstacles while also creating new challenges. Future studies should perhaps also consider alternative designs such as using surrogate (preferably continuous) markers of breast cancer, focusing on high-risk populations, and defining pathologically distinct outcomes.
Published Version: doi://10.1186/bcr1529
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779480/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:5978620

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