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dc.contributor.authorMicha, Renata
dc.contributor.authorMozaffarian, Dariush
dc.date.accessioned2011-12-24T04:08:51Z
dc.date.issued2010
dc.identifier.citationMicha, Renata, and Dariush Mozaffarian. 2010. Saturated fat and cardiometabolic risk factors, coronary heart disease, stroke, and diabetes: A fresh look at the evidence. Lipids 45(10): 893-905.en_US
dc.identifier.issn0024-4201en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:5978677
dc.description.abstractDietary and policy recommendations frequently focus on reducing saturated fatty acid consumption for improving cardiometabolic health, based largely on ecologic and animal studies. Recent advances in nutritional science now allow assessment of critical questions about health effects of saturated fatty acids (SFA). We reviewed the evidence from randomized controlled trials (RCTs) of lipid and non-lipid risk factors, prospective cohort studies of disease endpoints, and RCTs of disease endpoints for cardiometabolic effects of SFA consumption in humans, including whether effects vary depending on specific SFA chain-length; on the replacement nutrient; or on disease outcomes evaluated. Compared with carbohydrate, the TC:HDL-C ratio is nonsignificantly affected by consumption of myristic or palmitic acid, is nonsignificantly decreased by stearic acid, and is significantly decreased by lauric acid. However, insufficient evidence exists for different chain-length-specific effects on other risk pathways or, more importantly, disease endpoints. Based on consistent evidence from human studies, replacing SFA with polyunsaturated fat modestly lowers coronary heart disease risk, with ~10% risk reduction for a 5% energy substitution; whereas replacing SFA with carbohydrate has no benefit and replacing SFA with monounsaturated fat has uncertain effects. Evidence for the effects of SFA consumption on vascular function, insulin resistance, diabetes, and stroke is mixed, with many studies showing no clear effects, highlighting a need for further investigation of these endpoints. Public health emphasis on reducing SFA consumption without considering the replacement nutrient or, more importantly, the many other food-based risk factors for cardiometabolic disease is unlikely to produce substantial intended benefits.en_US
dc.language.isoen_USen_US
dc.publisherSpringer-Verlagen_US
dc.relation.isversionofdoi:10.1007/s11745-010-3393-4en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950931/pdf/en_US
dash.licenseLAA
dc.subjectcardiovascular diseaseen_US
dc.subjectdiabetes mellitusen_US
dc.subjectdieten_US
dc.subjectnutritionen_US
dc.subjectsaturated fatty acidsen_US
dc.subjectfatty acidsen_US
dc.titleSaturated Fat and Cardiometabolic Risk Factors, Coronary Heart Disease, Stroke, and Diabetes: A Fresh Look at the Evidenceen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalLipidsen_US
dash.depositing.authorMozaffarian, Dariush
dc.date.available2011-12-24T04:08:51Z
dash.affiliation.otherSPH^Epidemiologyen_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dc.identifier.doi10.1007/s11745-010-3393-4*
dash.contributor.affiliatedMozaffarian, Dariush


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