The Role of Particulate Matter-Associated Zinc in Cardiac Injury in Rats

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The Role of Particulate Matter-Associated Zinc in Cardiac Injury in Rats

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Title: The Role of Particulate Matter-Associated Zinc in Cardiac Injury in Rats
Author: Kodavanti, Urmila P.; Schladweiler, Mette C.; Gilmour, Peter S.; Wallenborn, J. Grace; Mandavilli, Bhaskar S.; Ledbetter, Allen D.; Runge, Marschall S.; Karoly, Edward D.; Peddada, Shyamal; Jaskot, Richard; Richards, Judy H.; Thomas, Ronald; Madamanchi, Nageswara R.; Nyska, Abraham; Christiani, David C.; Costa, Daniel L.

Note: Order does not necessarily reflect citation order of authors.

Citation: Kodavanti, Urmila P., Mette C. Schladweiler, Peter S. Gilmour, J. Grace Wallenborn, Bhaskar S. Mandavilli, Allen D. Ledbetter, David C. Christiani, et al. 2008. The role of particulate matter-associated zinc in cardiac injury in rats. Environmental Health Perspectives 116(1): 13-20.
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Abstract: Background: Exposure to particulate matter (PM) has been associated with increased cardiovascular morbidity; however, causative components are unknown. Zinc is a major element detected at high levels in urban air.Objective We investigated the role of PM-associated zinc in cardiac injury. Methods: We repeatedly exposed 12- to 14-week-old male Wistar Kyoto rats intratracheally (1×/week for 8 or16 weeks) to a) saline (control); b) PM having no soluble zinc (Mount St. Helens ash, MSH); or c) whole-combustion PM suspension containing 14.5 μg/mg of water-soluble zinc at high dose (PM-HD) and d ) low dose (PM-LD), e) the aqueous fraction of this suspension (14.5 μg/mg of soluble zinc) (PM-L), or f ) zinc sulfate (rats exposed for 8 weeks received double the concentration of all PM components of rats exposed for 16 weeks). Results: Pulmonary inflammation was apparent in all exposure groups when compared with saline (8 weeks greater than 16 weeks). PM with or without zinc, or with zinc alone caused small increases in focal subepicardial inflammation, degeneration, and fibrosis. Lesions were not detected in controls at 8 weeks but were noted at 16 weeks. We analyzed mitochondrial DNA damage using quantitative polymerase chain reaction and found that all groups except MSH caused varying degrees of damage relative to control. Total cardiac aconitase activity was inhibited in rats receiving soluble zinc. Expression array analysis of heart tissue revealed modest changes in mRNA for genes involved in signaling, ion channels function, oxidative stress, mitochondrial fatty acid metabolism, and cell cycle regulation in zinc but not in MSH-exposed rats. Conclusion: These results suggest that water-soluble PM-associated zinc may be one of the causal components involved in PM cardiac effects.
Published Version: doi:10.1289/ehp.10379
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2199289/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:5978681

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