Diffusion MRI of Structural Brain Plasticity Induced by a Learning and Memory Task
DSpace/Manakin Repository
Diffusion MRI of Structural Brain Plasticity Induced by a Learning and Memory Task
| Title: | Diffusion MRI of Structural Brain Plasticity Induced by a Learning and Memory Task |
| Author: |
Blumenfeld-Katzir, Tamar; Dagan, Michael; Assaf, Yaniv; Pasternak, Ofer
Note: Order does not necessarily reflect citation order of authors. |
| Citation: | Blumenfeld-Katzir, Tamar, Ofer Pasternak, Michael Dagan, and Yaniv Assaf. 2011. Diffusion MRI of structural brain plasticity induced by a learning and memory task. PLoS ONE 6(6): e20678. |
| Full Text & Related Files: |
3119075.pdf (1.297Mb; PDF) 
|
| Abstract: | Background: Activity-induced structural remodeling of dendritic spines and glial cells was recently proposed as an important factor in neuroplasticity and suggested to accompany the induction of long-term potentiation (LTP). Although T1 and diffusion MRI have been used to study structural changes resulting from long-term training, the cellular basis of the findings obtained and their relationship to neuroplasticity are poorly understood. Methodology/Principal Finding: Here we used diffusion tensor imaging (DTI) to examine the microstructural manifestations of neuroplasticity in rats that performed a spatial navigation task. We found that DTI can be used to define the selective localization of neuroplasticity induced by different tasks and that this process is age-dependent in cingulate cortex and corpus callosum and age-independent in the dentate gyrus. Conclusion/Significance: We relate the observed DTI changes to the structural plasticity that occurs in astrocytes and discuss the potential of MRI for probing structural neuroplasticity and hence indirectly localizing LTP. |
| Published Version: | doi:10.1371/journal.pone.0020678 |
| Other Sources: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119075/pdf/ |
| Terms of Use: | This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA |
| Citable link to this page: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:5978688 |
This item appears in the following Collection(s)
-
HMS Scholarly Articles [4046]
Contact administrator regarding this item (to report mistakes or request changes)
