Values for Preventing Influenza-related Morbidity and Vaccine Adverse Events in Children

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Values for Preventing Influenza-related Morbidity and Vaccine Adverse Events in Children

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dc.contributor.author Bridges, Carolyn Buxton
dc.contributor.author Uyeki, Timothy M
dc.contributor.author Rêgo, Virginia H
dc.contributor.author Ray, G Thomas
dc.contributor.author Meltzer, Martin I
dc.contributor.author Fukuda, Keiji
dc.contributor.author Prosser, Lisa Alison
dc.contributor.author Schwartz, Benjamin
dc.contributor.author Thompson, William W
dc.contributor.author Lieu, Tracy Ann
dc.date.accessioned 2011-12-29T05:48:41Z
dc.date.issued 2005
dc.identifier.citation Prosser, Lisa A., Carolyn Buxton Bridges, Timothy M. Uyeki, Virginia H. Rêgo, G. Thomas Ray, Martin I. Meltzer, Benjamin Schwartz, William W. Thompson, Keiji Fukuda, and Tracy A. Lieu. 2005. Values for preventing influenza-related morbidity and vaccine adverse events in children. Health and Quality of Life Outcomes 3: 18. en_US
dc.identifier.issn 1477-7525 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:5978700
dc.description.abstract Background: Influenza vaccination recently has been recommended for children 6–23 months old, but is not currently recommended for routine use in non-high-risk older children. Information on disease impact, costs, benefits, risks, and community preferences could help guide decisions about which age and risk groups should be vaccinated and strategies for improving coverage. The objective of this study was to measure preferences and willingness-to-pay for changes in health-related quality of life associated with uncomplicated influenza and two rarely-occurring vaccination-related adverse events (anaphylaxis and Guillain-Barré syndrome) in children. Methods: We conducted telephone interviews with adult members selected at random from a large New England HMO (n = 112). Respondents were given descriptions of four health outcomes: uncomplicated influenza in a hypothetical 1-year-old child of their own, uncomplicated influenza in a hypothetical 14-year-old child of their own, anaphylaxis following vaccination, and Guillain-Barré syndrome. "Uncomplicated influenza" did not require a physician's visit or hospitalization. Preferences (values) for these health outcomes were measured using time-tradeoff and willingness-to-pay questions. Time-tradeoff questions asked the adult to assume they had a child and to consider how much time from the end of their own life they would be willing to surrender to avoid the health outcome in the child. Results: Respondents said they would give a median of zero days of their lives to prevent an episode of uncomplicated influenza in either their (hypothetical) 1-year-old or 14-year-old, 30 days to prevent an episode of vaccination-related anaphylaxis, and 3 years to prevent a vaccination-related case of Guillain-Barré syndrome. Median willingness-to-pay to prevent uncomplicated influenza in a 1-year-old was $175, uncomplicated influenza in a 14-year-old was $100, anaphylaxis $400, and Guillain-Barré syndrome $4000. The median willingness-to-pay for an influenza vaccination for their children with no risk of anaphylaxis or Guillain-Barré syndrome was $50 and $100, respectively. Conclusion: Most respondents said they would not be willing to trade any time from their own lives to prevent uncomplicated influenza in a child of their own, and the time traded did not vary by the age of the hypothetical affected child. However, adults did indicate a willingness-to-pay to prevent uncomplicated influenza in children, and that they would give more money to prevent the illness in a 1-year-old than in a 14-year-old. Respondents also indicated a willingness to pay a premium for a vaccine without any risk of severe complications. en_US
dc.language.iso en_US en_US
dc.publisher BioMed Central en_US
dc.relation.isversionof doi:10.1186/1477-7525-3-18 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1083419/pdf/ en_US
dash.license LAA
dc.title Values for Preventing Influenza-related Morbidity and Vaccine Adverse Events in Children en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Health and Quality of Life Outcomes en_US
dash.depositing.author Prosser, Lisa Alison
dc.date.available 2011-12-29T05:48:41Z
dash.affiliation.other SPH^Health Policy and Management en_US
dash.affiliation.other HMS^Population Medicine en_US
dash.affiliation.other HMS^Pediatrics-Children's Hospital en_US

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