Cambogin is Preferentially Cytotoxic to Cells Expressing PDGFR

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Cambogin is Preferentially Cytotoxic to Cells Expressing PDGFR

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dc.contributor.author Wang, Fengfei
dc.contributor.author Xiao, Peigen
dc.contributor.author Yang, Junshan
dc.contributor.author Wu, Erxi
dc.contributor.author Tian, Ze
dc.contributor.author Shen, Jie
dc.contributor.author Lei, Hetian
dc.contributor.author Kazlauskas, Andrius
dc.contributor.author Kohane, Isaac Samuel
dc.date.accessioned 2011-12-30T02:21:46Z
dc.date.issued 2011
dc.identifier.citation Tian, Ze, Jie Shen, Fengfei Wang, Peigen Xiao, Junshan Yang, Hetian Lei, Andrius Kazlauskas, Isaac S. Kohane, and Erxi Wu. 2011. Cambogin is preferentially cytotoxic to cells expressing PDGFR. PLoS ONE 6(6): e21370. en_US
dc.identifier.issn 1932-6203 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:5978718
dc.description.abstract Platelet-derived growth factor receptors (PDGFRs) have been implicated in a wide array of human malignancies, including medulloblastoma (MB), the most common brain tumor of childhood. Although significant progress in MB biology and therapeutics has been achieved during the past decades, MB remains a horrible challenge to the physicians and researchers. Therefore, novel inhibitors targeting PDGFR signaling pathway may offer great promise for the treatment of MB. In the present study, we investigated the cytotoxicity and mechanisms of cambogin in Daoy MB cells. Our results show that cambogin triggers significant S phase cell cycle arrest and apoptosis via down regulation of cyclin A and E, and activation of caspases. More importantly, further mechanistic studies demonstrated that cambogin inhibits PDGFR signaling in Daoy and genetically defined mouse embryo fibroblast (MEF) cell lines. These results suggest that cambogin is preferentially cytotoxic to cells expressing PDGFR. Our findings may provide a novel approach by targeting PDGFR signaling against MB. en_US
dc.language.iso en_US en_US
dc.publisher Public Library of Science en_US
dc.relation.isversionof doi:10.1371/journal.pone.0021370 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119700/pdf/ en_US
dash.license LAA
dc.subject endocrine physiology en_US
dc.subject endocrine system en_US
dc.subject growth factors en_US
dc.subject cancer genetics en_US
dc.subject head and neck tumors en_US
dc.subject chemotherapy and drug treatment en_US
dc.subject molecular cell biology en_US
dc.subject cancers and neoplasms en_US
dc.title Cambogin is Preferentially Cytotoxic to Cells Expressing PDGFR en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal PLoS ONE en_US
dash.depositing.author Tian, Ze
dc.date.available 2011-12-30T02:21:46Z
dash.affiliation.other HMS^Medicine-Brigham and Women's Hospital en_US
dash.affiliation.other HMS^Countway Library of Medicine en_US
dash.affiliation.other HMS^Medicine-Brigham and Women's Hospital en_US
dash.affiliation.other HMS^Pediatrics-Children's Hospital en_US

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