Quantification of the Relative Importance of CTL, B Cell, NK Cell, and Target Cell Limitation in the Control of Primary SIV-Infection

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Quantification of the Relative Importance of CTL, B Cell, NK Cell, and Target Cell Limitation in the Control of Primary SIV-Infection

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dc.contributor.author Elemans, Marjet
dc.contributor.author Thiebaut, Rodolphe
dc.contributor.author Kaur, Amitinder
dc.contributor.author Asquith, Becca
dc.date.accessioned 2011-12-30T02:45:10Z
dc.date.issued 2011
dc.identifier.citation Elemans, Marjet, Rodolphe Thiebaut, Amitinder Kaur, and Becca Asquith. 2011. Quantification of the relative importance of CTL, B cell, NK cell, and target cell limitation in the control of primary SIV-infection. PLoS Computational Biology 7(3): e1001103. en_US
dc.identifier.issn 1553-734X en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:5978722
dc.description.abstract CD8\(^+\) cytotoxic T lymphocytes (CTLs), natural killer (NK) cells, B cells and target cell limitation have all been suggested to play a role in the control of SIV and HIV-1 infection. However, previous research typically studied each population in isolation leaving the magnitude, relative importance and in vivo relevance of each effect unclear. Here we quantify the relative importance of CTLs, NK cells, B cells and target cell limitation in controlling acute SIV infection in rhesus macaques. Using three different methods, we find that the availability of target cells and CD8\(^+\) T cells are important predictors of viral load dynamics. If CTL are assumed to mediate this anti-viral effect via a lytic mechanism then we estimate that CTL killing is responsible for approximately 40% of productively infected cell death, the remaining cell death being attributable to intrinsic, immune (CD8\(^+\) T cell, NK cell, B cell) -independent mechanisms. Furthermore, we find that NK cells have little impact on the death rate of infected CD4\(^+\) cells and that their net impact is to increase viral load. We hypothesize that NK cells play a detrimental role in SIV infection, possibly by increasing T cell activation. en_US
dc.language.iso en_US en_US
dc.publisher Public Library of Science en_US
dc.relation.isversionof 10.1371/journal.pcbi.1001103 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048377/pdf/ en_US
dash.license LAA
dc.title Quantification of the Relative Importance of CTL, B Cell, NK Cell, and Target Cell Limitation in the Control of Primary SIV-Infection en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal PLoS Computational Biology en_US
dash.depositing.author Kaur, Amitinder
dc.date.available 2011-12-30T02:45:10Z
dash.affiliation.other 100175 en_US

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