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dc.contributor.authorTonne, Cathryn
dc.contributor.authorMelly, Steven John
dc.contributor.authorMittleman, Murray A.
dc.contributor.authorCoull, Brent Andrew
dc.contributor.authorGoldberg, Robert
dc.contributor.authorSchwartz, Joel David
dc.date.accessioned2011-12-31T23:03:42Z
dc.date.issued2006
dc.identifier.citationTonne, Cathryn, Steve Melly, Murray Mittleman, Brent Coull, Robert Goldberg, and Joel Schwartz. 2007. A case-control analysis of exposure to traffic and acute myocardial infarction. Environmental Health Perspectives 115(1): 53-57.en_US
dc.identifier.issn0091-6765en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:5978724
dc.description.abstractBackground: Long-term exposure to particulate air pollution has been associated with an increased risk of dying from cardiopulmonary and ischemic heart disease, yet few studies have evaluated cardiovascular end points other than mortality. We investigated the relationship between long-term exposure to traffic and occurrence of acute myocardial infarction (AMI) in a case–control study. Methods: A total of 5,049 confirmed cases of AMI were identified between 1995 and 2003 as part of the Worcester Heart Attack Study, a community-wide study examining changes over time in the incidence of AMI among greater Worcester, Massachusetts, residents. Population controls were selected from Massachusetts resident lists. We used cumulative traffic within 100 m of subjects’ residence and distance from major roadway as proxies for exposure to traffic-related air pollution. We estimated the relationship between exposure to traffic and occurrence of AMI using logistic regression, and we adjusted for the following potential confounders: age, sex, section of the study area, point sources emissions of particulate matter with aerodynamic diameter < 2.5 μm, area socioeconomic characteristics, and percentage of open space. Results: An increase in cumulative traffic near the home was associated with a 4% increase in the odds of AMI per interquartile range [95% confidence interval (CI), 2–7%], whereas living near a major roadway was associated with a 5% increase in the odds of AMI per kilometer (95% CI, 3–6%). Conclusions: These results provide support for an association between long-term exposure to traffic and the risk of AMI.en_US
dc.language.isoen_USen_US
dc.publisherNational Institute of Environmental Health Sciencesen_US
dc.relation.isversionofdoi://10.1289/ehp.9587en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1797833/pdf/en_US
dash.licenseLAA
dc.subjectair pollutionen_US
dc.subjectcase-control studiesen_US
dc.subjectmyocardial infarctionen_US
dc.subjectvehicle emissionsen_US
dc.titleA Case–Control Analysis of Exposure to Traffic and Acute Myocardial Infarctionen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalEnvironmental Health Perspectivesen_US
dash.depositing.authorMittleman, Murray A.
dc.date.available2011-12-31T23:03:42Z
dash.affiliation.otherSPH^Epidemiologyen_US
dash.affiliation.otherHMS^Medicine- Beth Israel-Deaconessen_US
dash.affiliation.otherSPH^Biostatisticsen_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherSPH^Exposure Epidemiology and Risk Programen_US
dc.identifier.doi10.1289/ehp.9587*
dash.contributor.affiliatedMelly, Steven
dash.contributor.affiliatedCoull, Brent
dash.contributor.affiliatedMittleman, Murray
dash.contributor.affiliatedSchwartz, Joel
dc.identifier.orcid0000-0002-2557-150X


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