Lead Levels and Ischemic Heart Disease in a Prospective Study of Middle-Aged and Elderly Men: The VA Normative Aging Study

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Lead Levels and Ischemic Heart Disease in a Prospective Study of Middle-Aged and Elderly Men: The VA Normative Aging Study

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dc.contributor.author Potula, Vijayalakshmi
dc.contributor.author Nie, Huiling
dc.contributor.author Hu, Howard
dc.contributor.author Jain, Nitin
dc.contributor.author Schwartz, Joel David
dc.contributor.author Vokonas, Pantel S
dc.contributor.author Sparrow, David
dc.contributor.author Wright, Robert O.
dc.date.accessioned 2011-12-31T23:28:14Z
dc.date.issued 2007
dc.identifier.citation Jain, Nitin B., Vijayalakshmi Potula, Joel Schwartz, Pantel S. Vokonas, David Sparrow, Robert O. Wright, Huiling Nie, and Howard Hu. 2007. Lead levels and ischemic heart disease in a prospective study of middle-aged and elderly men: the VA normative aging study. Environmental Health Perspectives 115(6): 871-875. en_US
dc.identifier.issn 0091-6765 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:5978729
dc.description.abstract Background: Lead exposure has been associated with higher blood pressure, hypertension, electrocardiogram abnormalities, and increased mortality from circulatory causes.Objective We assessed the association between bone lead—a more accurate biomarker of chronic lead exposure than blood lead—and risk for future ischemic heart disease (IHD). Methods: In a prospective cohort study (VA Normative Aging Study), 837 men who underwent blood or bone lead measurements at baseline were followed-up for an ischemic heart disease event between 1 September 1991 and 31 December 2001. IHD was defined as either a diagnosis of myocardial infarction or angina pectoris that was confirmed by a cardiologist. Events of fatal myocardial infarction were assessed from death certificates. Results: An IHD event occurred in 83 cases (70 nonfatal and 13 fatal). The mean blood, tibia, and patella lead levels were higher in IHD cases than in noncases. In multivariate Cox-proportional hazards models, one standard deviation increase in blood lead level was associated with a 1.27 (95% confidence interval, 1.01–1.59) fold greater risk for ischemic heart disease. Similarly, a one standard deviation increase in patella and tibia lead levels was associated with greater risk for IHD (hazard ratio for patella lead = 1.29; 95% confidence interval, 1.02–1.62). Conclusions: Men with increased blood and bone lead levels were at increased risk for future IHD. Although the pathogenesis of IHD is multifactorial, lead exposure may be one of the risk factors. en_US
dc.language.iso en_US en_US
dc.publisher National Institute of Environmental Health Sciences en_US
dc.relation.isversionof doi://10.1289/ehp.9629 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892138/pdf/ en_US
dash.license LAA
dc.subject angina en_US
dc.subject epidemiology en_US
dc.subject myocardial infarction en_US
dc.title Lead Levels and Ischemic Heart Disease in a Prospective Study of Middle-Aged and Elderly Men: The VA Normative Aging Study en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Environmental Health Perspectives en_US
dash.depositing.author Jain, Nitin
dc.date.available 2011-12-31T23:28:14Z
dash.affiliation.other HMS^Orthopedic Surgery-Brigham and Women's Hospital en_US
dash.affiliation.other HMS^Medicine-Brigham and Women's Hospital en_US
dash.affiliation.other SPH^Exposure Epidemiology and Risk Program en_US
dash.affiliation.other HMS^Medicine-Brigham and Women's Hospital en_US
dash.affiliation.other HMS^Medicine-Brigham and Women's Hospital en_US
dash.affiliation.other SPH^Environmental+Occupational Medicine+Epi en_US
dash.affiliation.other HMS^Pediatrics-Children's Hospital en_US

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