The Upper Airway Response to Pollen is Enhanced by Exposure to Combustion Particulates: A Pilot Human Experimental Challenge Study.

DSpace/Manakin Repository

The Upper Airway Response to Pollen is Enhanced by Exposure to Combustion Particulates: A Pilot Human Experimental Challenge Study.

Show simple item record

dc.contributor.author Rice, Timothy M
dc.contributor.author Krishna Murthy, G G
dc.contributor.author Wand, Matt P
dc.contributor.author Bledsoe, Toni
dc.contributor.author Paulauskis, Joseph
dc.contributor.author Hauser, Russ B.
dc.contributor.author Lewis, Daniel
dc.date.accessioned 2012-01-01T22:37:09Z
dc.date.issued 2003
dc.identifier.citation Hauser, Russ, Timothy M. Rice, G G Krishna Murthy, Matt P. Wand, Daniel Lewis, Toni Bledsoe, and Joseph Paulauskis. 2003. The upper airway response to pollen is enhanced by exposure to combustion particulates: A pilot human experimental challenge study. Environmental Health Perspectives 111(4): 472-477. en_US
dc.identifier.issn 0091-6765 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:5978732
dc.description.abstract Although human experimental studies have shown that gaseous pollutants enhance the inflammatory response to allergens, human data on whether combustion particulates enhance the inflammatory response to allergen are limited. Therefore, we conducted a human experimental study to investigate whether combustion particulates enhance the inflammatory response to aeroallergens. "Enhancement" refers to a greater-than-additive response when combustion particulates are delivered with allergen, compared with the responses when particulates and allergen are delivered alone. Eight subjects, five atopic and three nonatopic, participated in three randomized exposure-challenge sessions at least 2 weeks apart (i.e., clean air followed by allergen, particles followed by no allergen, or particles followed by allergen). Each session consisted of nasal exposure to combustion particles (target concentration of 1.0 mg/m\(^3\)) or clean air for 1 hr, followed 3 hr later by challenge with whole pollen grains or placebo. Nasal lavage was performed immediately before particle or clean air exposure, immediately after exposure, and 4, 18 and 42 hr after pollen challenge. Cell counts, differentials, and measurement of cytokines were performed on each nasal lavage. In atopic but not in nonatopic subjects, when allergen was preceded by particulates, there was a significant enhancement immediately after pollen challenge in nasal lavage leukocytes and neutrophils (29.7 X 10\(^3\) cells/mL and 25.4 X 10\(^3\) cells/mL, respectively). This represents a 143% and 130% enhancement, respectively. The enhanced response for interleukin-4 was 3.23 pg/mL (p = 0.06), a 395% enhancement. In atopic subjects there was evidence of an enhanced response when particulates, as compared to clean air, preceded the allergen challenge. en_US
dc.language.iso en_US en_US
dc.publisher National Institute of Environmental Health Sciences en_US
dc.relation.isversionof doi:10.1289/ehp.5862 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1241430/pdf/ en_US
dash.license LAA
dc.subject allergy en_US
dc.subject atopy en_US
dc.subject cytokines en_US
dc.subject inflammatory cells en_US
dc.subject particulates en_US
dc.title The Upper Airway Response to Pollen is Enhanced by Exposure to Combustion Particulates: A Pilot Human Experimental Challenge Study. en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Environmental Health Perspectives en_US
dash.depositing.author Hauser, Russ B.
dc.date.available 2012-01-01T22:37:09Z
dash.affiliation.other HMS^Obstetrics Gynecology and Repro. Bio. - MGH en_US
dash.affiliation.other SPH^Environmental+Occupational Medicine+Epi en_US

Files in this item

Files Size Format View
1241430.pdf 151.3Kb PDF View/Open

This item appears in the following Collection(s)

Show simple item record

 
 

Search DASH


Advanced Search
 
 

Submitters