Antibody Responses after Intravaginal Immunisation with Trimeric HIV-1CN54 clade C gp140 in Carbopol Gel are Augmented by Systemic Priming or Boosting with an Adjuvanted Formulation

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Antibody Responses after Intravaginal Immunisation with Trimeric HIV-1CN54 clade C gp140 in Carbopol Gel are Augmented by Systemic Priming or Boosting with an Adjuvanted Formulation

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Title: Antibody Responses after Intravaginal Immunisation with Trimeric HIV-1CN54 clade C gp140 in Carbopol Gel are Augmented by Systemic Priming or Boosting with an Adjuvanted Formulation
Author: Cranage, Martin P.; Fraser, Carol A.; Cope, Alethea; McKay, Paul F.; Cole, Tom; Mahmoud, A. Nasir; Hall, Joanna; Giles, Elaine; Voss, Gerald; Page, Mark; Almond, Neil; Shattock, Robin J.; Seaman, Michael S.

Note: Order does not necessarily reflect citation order of authors.

Citation: Cranage, Martin P., Carol A. Fraser, Alethea Cope, Paul F. McKay, Michael S. Seaman, Tom Cole, A. Nasir Mahmoud, et al. 2011. Antibody responses after intravaginal immunisation with trimeric HIV-1CN54 clade C gp140 in Carbopol gel are augmented by systemic priming or boosting with an adjuvanted formulation. Vaccine 29(7): 1421-1430.
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Abstract: Optimum strategies to elicit and maintain antibodies at mucosal portals of virus entry are critical for the development of vaccines against human immunodeficiency virus (HIV). Here we show in non-human primates that a novel regimen of repeated intravaginal delivery of a non-adjuvanted, soluble recombinant trimeric HIV-1\(_{CN54}\) clade C envelope glycoprotein (gp140) administered in Carbopol gel can prime for B-cell responses even in the absence of seroconversion. Following 3 cycles of repeated intravaginal administration, throughout each intermenses interval, 3 of 4 macaques produced or boosted systemic and mucosally-detected antibodies upon intramuscular immunisation with gp140 formulated in AS01 adjuvant. Reciprocally, a single intramuscular immunisation primed 3 of 4 macaques for antibody boosting after a single cycle of intravaginal immunisation. Virus neutralising activity was detected against clade C and clade B HIV-1 envelopes but was restricted to highly neutralisation sensitive pseudoviruses.
Published Version: doi:10.1016/j.vaccine.2010.12.034
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060343/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:5978759

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