Calcineurin Regulates Innate Antifungal Immunity in Neutrophils

DSpace/Manakin Repository

Calcineurin Regulates Innate Antifungal Immunity in Neutrophils

Citable link to this page

. . . . . .

Title: Calcineurin Regulates Innate Antifungal Immunity in Neutrophils
Author: Hu, Bella; Aliprantis, Antonios O.; Glimcher, Laurie Hollis; Greenblatt, Matthew Blake

Note: Order does not necessarily reflect citation order of authors.

Citation: Greenblatt, Matthew B., Antonios Aliprantis, Bella Hu, and Laurie H. Glimcher. 2010. Calcineurin regulates innate antifungal immunity in neutrophils. Journal of Experimental Medicine 207(5): 923-931.
Full Text & Related Files:
Abstract: Patients taking immunosuppressive drugs, like cyclosporine A (CsA), that inhibit calcineurin are highly susceptible to disseminated fungal infections, although it is unclear how these drugs suppress resistance to these opportunistic pathogens. We show that in a mouse model of disseminated Candida albicans infection, CsA-induced susceptibility to fungal infection maps to the innate immune system. To further define the cell types targeted by CsA, we generated mice with a conditional deletion of calcineurin B (CnB) in neutrophils. These mice displayed markedly decreased resistance to infection with C. albicans, and both CnB-deficient and CsA-treated neutrophils showed a defect in the ex vivo killing of C. albicans. In response to the fungal-derived pathogen-associated molecular pattern zymosan, neutrophils lacking CnB displayed impaired up-regulation of genes (IL-10, Cox2, Egr1, and Egr2) regulated by nuclear factor of activated T cells, the best characterized CnB substrate. This activity was Myd88 independent and was reproduced by stimulation with the β(1,3) glucan curdlan, indicating that dectin-1, rather than toll-like receptors, is the upstream activator of calcineurin. Our results suggest that disseminated fungal infections seen in CsA-treated patients are not just a general consequence of systemic suppression of adaptive immunity but are, rather, a result of the specific blockade of evolutionarily conserved innate pathways for fungal resistance.
Published Version: doi:10.1084/jem.20092531
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867274/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:6348645

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters