Ambient and Microenvironmental Particles and Exhaled Nitric Oxide Before and After a Group Bus Trip

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Ambient and Microenvironmental Particles and Exhaled Nitric Oxide Before and After a Group Bus Trip

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dc.contributor.author Adar, Sara Dubowsky
dc.contributor.author Adamkiewicz, Gary
dc.contributor.author Gold, Diane R.
dc.contributor.author Schwartz, Joel David
dc.contributor.author Coull, Brent Andrew
dc.contributor.author Suh MacIntosh, Helen H.
dc.date.accessioned 2012-01-05T04:47:36Z
dc.date.issued 2007
dc.identifier.citation Adar, Sara Dubowsky, Gary Adamkiewicz, Diane R. Gold, Joel Schwartz, Brent A. Coull, and Helen Suh. 2007. Ambient and microenvironmental particles and exhaled nitric oxide before and after a group bus trip. Environmental Health Perspectives 115(4): 507-512. en_US
dc.identifier.issn 0091-6765 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:6526731
dc.description.abstract Objectives: Airborne particles have been linked to pulmonary oxidative stress and inflammation. Because these effects may be particularly great for traffic-related particles, we examined associations between particle exposures and exhaled nitric oxide (FENO) in a study of 44 senior citizens, which involved repeated trips aboard a diesel bus. Methods: Samples of FENO collected before and after the trips were regressed against microenvironmental and ambient particle concentrations using mixed models controlling for subject, day, trip, vitamins, collection device, mold, pollen, room air nitric oxide, apparent temperature, and time to analysis. Although ambient concentrations were collected at a fixed location, continuous group-level personal samples characterized microenvironmental exposures throughout facility and trip periods. Results: In pre-trip samples, both microenvironmental and ambient exposures to fine particles were positively associated with FENO. For example, an interquartile increase of 4 μg/m3 in the daily microenvironmental PM2.5 concentration was associated with a 13% [95% confidence interval (CI), 2–24%) increase in FENO. After the trips, however, FENO concentrations were associated pre-dominantly with microenvironmental exposures, with significant associations for concentrations measured throughout the whole day. Associations with exposures during the trip also were strong and statistically significant with a 24% (95% CI, 15–34%) increase in FENO predicted per interquartile increase of 9 μg/m3 in PM2.5. Although pre-trip findings were generally robust, our post-trip findings were sensitive to several influential days. Conclusions: Fine particle exposures resulted in increased levels of FENO in elderly adults, suggestive of increased airway inflammation. These associations were best assessed by microenvironmental exposure measurements during periods of high personal particle exposures. en_US
dc.language.iso en_US en_US
dc.publisher National Institute of Environmental Health Sciences en_US
dc.relation.isversionof doi:10.1289/ehp.9386 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1852653/pdf/ en_US
dash.license LAA
dc.subject air pollution en_US
dc.subject exhaled nitric oxide en_US
dc.subject inflammation en_US
dc.subject particulate matter en_US
dc.subject traffic en_US
dc.title Ambient and Microenvironmental Particles and Exhaled Nitric Oxide Before and After a Group Bus Trip en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Environmental Health Perspectives en_US
dash.depositing.author Adamkiewicz, Gary
dc.date.available 2012-01-05T04:47:36Z
dash.affiliation.other SPH^Exposure Epidemiology and Risk Program en_US
dash.affiliation.other HMS^Medicine-Brigham and Women's Hospital en_US
dash.affiliation.other SPH^Exposure Epidemiology and Risk Program en_US
dash.affiliation.other HMS^Medicine-Brigham and Women's Hospital en_US
dash.affiliation.other SPH^Exposure Epidemiology and Risk Program en_US
dash.affiliation.other SPH^Biostatistics en_US

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