JunB Transcription Factor Maintains Skeletal Muscle Mass and Promotes Hypertrophy

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JunB Transcription Factor Maintains Skeletal Muscle Mass and Promotes Hypertrophy

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dc.contributor.author Raffaello, Anna
dc.contributor.author Milan, Giulia
dc.contributor.author Masiero, Eva
dc.contributor.author Carnio, Silvia
dc.contributor.author Lanfranchi, Gerolamo
dc.contributor.author Sandri, Marco
dc.contributor.author Goldberg, Alfred L.
dc.contributor.author Lee, Dong-Hoon
dc.date.accessioned 2012-01-09T20:11:40Z
dc.date.issued 2010
dc.identifier.citation Raffaello, Anna, Giulia Milan, Eva Masiero, Silvia Carnio, Dong-Hoon Lee, Gerolamo Lanfranchi, Alfred Lewis Goldberg, and Marco Sandri. 2010. JunB transcription factor maintains skeletal muscle mass and promotes hypertrophy. The Journal of Cell Biology 191(1): 101-113. en_US
dc.identifier.issn 0021-9525 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:7351760
dc.description.abstract The size of skeletal muscle cells is precisely regulated by intracellular signaling networks that determine the balance between overall rates of protein synthesis and degradation. Myofiber growth and protein synthesis are stimulated by the IGF-1/Akt/mammalian target of rapamycin (mTOR) pathway. In this study, we show that the transcription factor JunB is also a major determinant of whether adult muscles grow or atrophy. We found that in atrophying myotubes, JunB is excluded from the nucleus and that decreasing JunB expression by RNA interference in adult muscles causes atrophy. Furthermore, JunB overexpression induces hypertrophy without affecting satellite cell proliferation and stimulated protein synthesis independently of the Akt/mTOR pathway. When JunB is transfected into denervated muscles, fiber atrophy is prevented. JunB blocks FoxO3 binding to atrogin-1 and MuRF-1 promoters and thus reduces protein breakdown. Therefore, JunB is important not only in dividing populations but also in adult muscle, where it is required for the maintenance of muscle size and can induce rapid hypertrophy and block atrophy. en_US
dc.language.iso en_US en_US
dc.publisher The Rockefeller University Press en_US
dc.relation.isversionof doi://10.1083/jcb.201001136 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2953439/pdf/ en_US
dash.license LAA
dc.title JunB Transcription Factor Maintains Skeletal Muscle Mass and Promotes Hypertrophy en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal The Journal of Cell Biology en_US
dash.depositing.author Goldberg, Alfred L.
dc.date.available 2012-01-09T20:11:40Z
dash.affiliation.other HMS^Cell Biology en_US
dash.affiliation.other HMS^Cell Biology en_US

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