Gene Surfing in Expanding Populations

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Gene Surfing in Expanding Populations

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dc.contributor.author Hallatschek, Oskar
dc.contributor.author Nelson, David R.
dc.date.accessioned 2012-01-19T20:03:23Z
dc.date.issued 2008
dc.identifier.citation Hallatschek, Oskar, and David Nelson. 2008. Gene surfing in expanding populations. Theoretical Population Biology 73(1): 158-170. en_US
dc.identifier.issn 0040-5809 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:7982716
dc.description.abstract Spatially resolved genetic data is increasingly used to reconstruct the migrational history of species. To assist such inference, we study, by means of simulations and analytical methods, the dynamics of neutral gene frequencies in a population undergoing a continual range expansion in one dimension. During such a colonization period, lineages can fix at the wave front by means of a "surfing" mechanism [Edmonds C.A., Lillie A.S. & Cavalli-Sforza L.L. (2004) Proc Natl Acad Sci USA 101: 975-979]. We quantify this phenomenon in terms of (i) the spatial distribution of lineages that reach fixation and, closely related, (ii) the continual loss of genetic diversity (heterozygosity) at the wave front, characterizing the approach to fixation. Our simulations show that an effective population size can be assigned to the wave that controls the (observable) gradient in heterozygosity left behind the colonization process. This effective population size is markedly higher in pushed waves than in pulled waves, and increases only sub-linearly with deme size. To explain these and other findings, we develop a versatile analytical approach, based on the physics of reaction-diffusion systems, that yields simple predictions for any deterministic population dynamics. en_US
dc.description.sponsorship Physics en_US
dc.language.iso en_US en_US
dc.publisher Elsevier en_US
dc.relation.isversionof doi:10.1016/j.tpb.2007.08.008 en_US
dc.relation.hasversion http://arxiv.org/abs/q-bio/0703040v1 en_US
dash.license LAA
dc.subject random genetic drift en_US
dc.subject range expansions en_US
dc.subject neutral evolution en_US
dc.subject coalescent en_US
dc.subject Fisher wave en_US
dc.subject populations and evolution en_US
dc.title Gene Surfing in Expanding Populations en_US
dc.type Journal Article en_US
dc.description.version Author's Original en_US
dc.relation.journal Theoretical Population Biology en_US
dash.depositing.author Nelson, David R.
dc.date.available 2012-01-19T20:03:23Z

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  • FAS Scholarly Articles [7470]
    Peer reviewed scholarly articles from the Faculty of Arts and Sciences of Harvard University

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