Gene Surfing in Expanding Populations

Gene Surfing in Expanding Populations

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Gene Surfing in Expanding Populations

dc.contributor.author	Hallatschek, Oskar
dc.contributor.author	Nelson, David R.
dc.date.accessioned	2012-01-19T20:03:23Z
dc.date.issued	2008
dc.identifier.citation	Hallatschek, Oskar, and David Nelson. 2008. Gene surfing in expanding populations. Theoretical Population Biology 73(1): 158-170.	en_US
dc.identifier.issn	0040-5809	en_US
dc.identifier.uri	http://nrs.harvard.edu/urn-3:HUL.InstRepos:7982716
dc.description.abstract	Spatially resolved genetic data is increasingly used to reconstruct the migrational history of species. To assist such inference, we study, by means of simulations and analytical methods, the dynamics of neutral gene frequencies in a population undergoing a continual range expansion in one dimension. During such a colonization period, lineages can fix at the wave front by means of a "surfing" mechanism [Edmonds C.A., Lillie A.S. & Cavalli-Sforza L.L. (2004) Proc Natl Acad Sci USA 101: 975-979]. We quantify this phenomenon in terms of (i) the spatial distribution of lineages that reach fixation and, closely related, (ii) the continual loss of genetic diversity (heterozygosity) at the wave front, characterizing the approach to fixation. Our simulations show that an effective population size can be assigned to the wave that controls the (observable) gradient in heterozygosity left behind the colonization process. This effective population size is markedly higher in pushed waves than in pulled waves, and increases only sub-linearly with deme size. To explain these and other findings, we develop a versatile analytical approach, based on the physics of reaction-diffusion systems, that yields simple predictions for any deterministic population dynamics.	en_US
dc.description.sponsorship	Physics	en_US
dc.language.iso	en_US	en_US
dc.publisher	Elsevier	en_US
dc.relation.isversionof	doi:10.1016/j.tpb.2007.08.008	en_US
dc.relation.hasversion	http://arxiv.org/abs/q-bio/0703040v1	en_US
dash.license	LAA
dc.subject	random genetic drift	en_US
dc.subject	range expansions	en_US
dc.subject	neutral evolution	en_US
dc.subject	coalescent	en_US
dc.subject	Fisher wave	en_US
dc.subject	populations and evolution	en_US
dc.title	Gene Surfing in Expanding Populations	en_US
dc.type	Journal Article	en_US
dc.description.version	Author's Original	en_US
dc.relation.journal	Theoretical Population Biology	en_US
dash.depositing.author	Nelson, David R.
dc.date.available	2012-01-19T20:03:23Z