Low-level Environmental Lead Exposure and Children’s Intellectual Function: An International Pooled Analysis

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Low-level Environmental Lead Exposure and Children’s Intellectual Function: An International Pooled Analysis

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Title: Low-level Environmental Lead Exposure and Children’s Intellectual Function: An International Pooled Analysis
Author: Lanphear, Bruce P.; Hornung, Richard; Khoury, Jane; Yolton, Kimberly; Baghurst, Peter; Canfield, Richard L.; Dietrich, Kim N.; Bornschein, Robert; Greene, Tom; Needleman, Herbert L.; Schnaas, Lourdes; Wasserman, Gail; Graziano, Joseph; Roberts, Russell; Bellinger, David C.; Rothenberg, Stephen J.

Note: Order does not necessarily reflect citation order of authors.

Citation: Lanphear, Bruce P., Richard Hornung, Jane Khoury, Kimberly Yolton, Peter Baghurst, David C. Bellinger, Richard L. Canfield, et al. 2005. Low-level environmental lead exposure and children’s intellectual function: an international pooled analysis. Environmental Health Perspectives 113(7): 894-899.
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Abstract: Lead is a confirmed neurotoxin, but questions remain about lead-associated intellectual deficits at blood lead levels < 10 μg/dL and whether lower exposures are, for a given change in exposure, associated with greater deficits. The objective of this study was to examine the association of intelligence test scores and blood lead concentration, especially for children who had maximal measured blood lead levels < 10 μg/dL. We examined data collected from 1,333 children who participated in seven international population-based longitudinal cohort studies, followed from birth or infancy until 5–10 years of age. The full-scale IQ score was the primary outcome measure. The geometric mean blood lead concentration of the children peaked at 17.8 μg/dL and declined to 9.4 μg/dL by 5–7 years of age; 244 (18%) children had a maximal blood lead concentration < 10 μg/dL, and 103 (8%) had a maximal blood lead concentration < 7.5 μg/dL. After adjustment for covariates, we found an inverse relationship between blood lead concentration and IQ score. Using a log-linear model, we found a 6.9 IQ point decrement [95% confidence interval (CI), 4.2–9.4] associated with an increase in concurrent blood lead levels from 2.4 to 30 μg/dL. The estimated IQ point decrements associated with an increase in blood lead from 2.4 to 10 μg/dL, 10 to 20 μg/dL, and 20 to 30 μg/dL were 3.9 (95% CI, 2.4–5.3), 1.9 (95% CI, 1.2–2.6), and 1.1 (95% CI, 0.7–1.5), respectively. For a given increase in blood lead, the lead-associated intellectual decrement for children with a maximal blood lead level < 7.5 μg/dL was significantly greater than that observed for those with a maximal blood lead level ≥7.5 μg/dL (p = 0.015). We conclude that environmental lead exposure in children who have maximal blood lead levels < 7.5 μg/dL is associated with intellectual deficits.
Published Version: doi://10.1289/ehp.7688
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1257652/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:8000911

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