Rare Lymphoid Malignancies of the Breast: A Report of Two Cases Illustrating Potential Diagnostic Pitfalls

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Rare Lymphoid Malignancies of the Breast: A Report of Two Cases Illustrating Potential Diagnostic Pitfalls

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dc.contributor.author Zuckerman, Dan S.
dc.contributor.author Farkash, Evan Andrew
dc.contributor.author Ferry, Judith Ann
dc.contributor.author Harris, Nancy Lee
dc.contributor.author Hochberg, Ephraim Paul
dc.contributor.author Takvorian, Ronald Wayne
dc.contributor.author Sohani, Aliyah
dc.date.accessioned 2012-01-30T03:52:16Z
dc.date.issued 2009
dc.identifier.citation Farkash, Evan A., Judith A. Ferry, Nancy Lee Harris, Ephraim P. Hochberg, Ronald W. Takvorian, Dan S. Zuckerman, and Aliyah R. Sohani. 2009. Rare lymphoid malignancies of the breast: a report of two cases illustrating potential diagnostic pitfalls. Journal of Hematopathology 2(4): 237-244. en_US
dc.identifier.issn 1865-5785 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:8063395
dc.description.abstract Breast involvement by lymphoma is uncommon and poses challenges in diagnosis. Lymphomas may clinically, radiologically, and morphologically mimic both benign and neoplastic conditions. We describe two cases of lymphoid malignancies predominantly involving the breast, both presenting diagnostic dilemmas. The first case, ALK-negative anaplastic large-cell lymphoma involving a seroma associated with a breast implant, is an emerging clinicopathologic entity. Anaplastic large-cell lymphoma has been identified in association with breast implants and seroma formation relatively recently. The second case, hairy cell leukemia involving the breast and ipsilateral axillary sentinel lymph node, is, to our knowledge, the first reported case of hairy cell leukemia involving the breast at the time of diagnosis. While a localized bone lesion was present at time of diagnosis, bone marrow involvement was relatively mild in comparison to that seen in the breast and lymph node. In the first case, lymphoma occurred in a clinical setting where malignancy was unsuspected, highlighting the importance of careful morphologic evaluation of paucicellular samples, as well as awareness of rare clinicopathologic entities, in avoiding a misdiagnosis of a benign inflammatory infiltrate. In the second case, the lymphoid neoplasm exhibited classic morphologic and immunophenotypic features, but presented at an unusual site of involvement. Knowledge of the patient's concurrent diagnosis of hairy cell leukemia involving the bone marrow and bone helped avoid a misdiagnosis of carcinoma rather than lymphoma. en_US
dc.language.iso en_US en_US
dc.publisher Springer-Verlag en_US
dc.relation.isversionof doi: 10.1007/s12308-009-0043-y en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798933/pdf/ en_US
dash.license LAA
dc.subject anaplastic large cell lymphoma en_US
dc.subject anaplastic lymphoma kinase en_US
dc.subject breast implant en_US
dc.subject hairy cell leukemia en_US
dc.subject primary breast lymphoma en_US
dc.subject seroma en_US
dc.subject T-cell neoplasm en_US
dc.title Rare Lymphoid Malignancies of the Breast: A Report of Two Cases Illustrating Potential Diagnostic Pitfalls en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Journal of Hematopathology en_US
dash.depositing.author Farkash, Evan Andrew
dc.date.available 2012-01-30T03:52:16Z
dash.affiliation.other HMS^Pathology en_US
dash.affiliation.other HMS^Pathology en_US
dash.affiliation.other HMS^Pathology en_US

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