Absolute Enrichment: Gene Set Enrichment Analysis for Homeostatic Systems

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Title:	Absolute Enrichment: Gene Set Enrichment Analysis for Homeostatic Systems
Author:	Saxena, Vishal; Orgill, Dennis Paul; Kohane, Isaac Samuel Note: Order does not necessarily reflect citation order of authors.
Citation:	Saxena, Vishal, Dennis Orgill, and Isaac Kohane. 2006. Absolute enrichment: gene set enrichment analysis for homeostatic systems. Nucleic Acids Research 34, no. 22: e151.
Full Text & Related Files:	1702493.pdf (618.7Kb; PDF)
Abstract:	The Gene Set Enrichment Analysis (GSEA) identifies sets of genes that are differentially regulated in one direction. Many homeostatic systems will include one limb that is upregulated in response to a downregulation of another limb and vice versa. Such patterns are poorly captured by the standard formulation of GSEA. We describe a technique to identify groups of genes (which sometimes can be pathways) that include both up- and down-regulated components. This approach lends insights into the feedback mechanisms that may operate, especially when integrated with protein interaction databases.
Published Version:	doi://10.1093/nar/gkl766
Other Sources:	http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1702493/pdf/
Terms of Use:	This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page:	http://nrs.harvard.edu/urn-3:HUL.InstRepos:8123170