Absolute Enrichment: Gene Set Enrichment Analysis for Homeostatic Systems

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Absolute Enrichment: Gene Set Enrichment Analysis for Homeostatic Systems

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dc.contributor.author Saxena, Vishal
dc.contributor.author Orgill, Dennis Paul
dc.contributor.author Kohane, Isaac Samuel
dc.date.accessioned 2012-02-04T22:23:04Z
dc.date.issued 2006
dc.identifier.citation Saxena, Vishal, Dennis Orgill, and Isaac Kohane. 2006. Absolute enrichment: gene set enrichment analysis for homeostatic systems. Nucleic Acids Research 34, no. 22: e151. en_US
dc.identifier.issn 0305-1048 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:8123170
dc.description.abstract The Gene Set Enrichment Analysis (GSEA) identifies sets of genes that are differentially regulated in one direction. Many homeostatic systems will include one limb that is upregulated in response to a downregulation of another limb and vice versa. Such patterns are poorly captured by the standard formulation of GSEA. We describe a technique to identify groups of genes (which sometimes can be pathways) that include both up- and down-regulated components. This approach lends insights into the feedback mechanisms that may operate, especially when integrated with protein interaction databases. en_US
dc.language.iso en_US en_US
dc.publisher Oxford University Press en_US
dc.relation.isversionof doi://10.1093/nar/gkl766 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1702493/pdf/ en_US
dash.license LAA
dc.title Absolute Enrichment: Gene Set Enrichment Analysis for Homeostatic Systems en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Nucleic Acids Research en_US
dash.depositing.author Kohane, Isaac Samuel
dc.date.available 2012-02-04T22:23:04Z
dash.affiliation.other HMS^Neurology-Massachusetts General Hospital en_US
dash.affiliation.other HMS^Surgery-Brigham and Women's Hospital en_US
dash.affiliation.other HMS^Countway Library of Medicine en_US
dash.affiliation.other HMS^Medicine-Brigham and Women's Hospital en_US
dash.affiliation.other HMS^Pediatrics-Children's Hospital en_US

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