Cross Species Genomic Analysis Identifies a Mouse Model as Undifferentiated Pleomorphic Sarcoma/Malignant Fibrous Histiocytoma

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Cross Species Genomic Analysis Identifies a Mouse Model as Undifferentiated Pleomorphic Sarcoma/Malignant Fibrous Histiocytoma

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Title: Cross Species Genomic Analysis Identifies a Mouse Model as Undifferentiated Pleomorphic Sarcoma/Malignant Fibrous Histiocytoma
Author: Mito, Jeffrey K.; Riedel, Richard F.; Dodd, Leslie; Lahat, Guy; Lazar, Alexander J.; Dodd, Rebecca D.; Stangenberg, Lars; Eward, William C.; Brigman, Brian E.; Jacks, Tyler; Lev, Dina; Mukherjee, Sayan; Kirsch, David G.; Aziz, Syed A.; Hornicek, Francis John; Yoon, Sam Sunghyun

Note: Order does not necessarily reflect citation order of authors.

Citation: Mito, Jeffrey K., Richard F. Riedel, Leslie Dodd, Guy Lahat, Alexander J. Lazar, Rebecca D. Dodd, Lars Stangenberg, et al. 2009. Cross Species Genomic Analysis Identifies a Mouse Model as Undifferentiated Pleomorphic Sarcoma/Malignant Fibrous Histiocytoma. PLoS ONE 4(11): e8075.
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Abstract: Undifferentiated pleomorphic sarcoma/Malignant Fibrous Histiocytoma (MFH) is one of the most common subtypes of human soft tissue sarcoma. Using cross species genomic analysis, we define a geneset from the \(LSL\)-\(Kras^{G12D}\); \(Trp53^{Flox/Flox}\) mouse model of soft tissue sarcoma that is highly enriched in human MFH. With this mouse geneset as a filter, we identify expression of the RAS target FOXM1 in human MFH. Expression of \(Foxm1\) is elevated in mouse sarcomas that metastasize to the lung and tissue microarray analysis of human MFH correlates overexpression of FOXM1 with metastasis. These results suggest that genomic alterations present in human MFH are conserved in the \(LSL\)-\(Kras^{G12D}\); \(p53^{Flox/Flox}\) mouse model of soft tissue sarcoma and demonstrate the utility of this pre-clinical model.
Published Version: doi://10.1371/journal.pone.0008075
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779485/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:8123176

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