Defining the Role of the MHC in Autoimmunity: A Review and Pooled Analysis

DSpace/Manakin Repository

Defining the Role of the MHC in Autoimmunity: A Review and Pooled Analysis

Citable link to this page

. . . . . .

Title: Defining the Role of the MHC in Autoimmunity: A Review and Pooled Analysis
Author: Fernando, Michelle M. A.; Stevens, Christine R.; Walsh, Emily C.; De Jager, Philip Lawrence; Goyette, Philippe; Plenge, Robert M.; Vyse, Timothy J.; Rioux, John D.

Note: Order does not necessarily reflect citation order of authors.

Citation: Fernando, Michelle M. A., Christine R. Stevens, Emily C. Walsh, Philip L. De Jager, Philippe Goyette, Robert M. Plenge, Timothy J. Vyse, and John D. Rioux. 2008. Defining the role of the MHC in autoimmunity: a review and pooled analysis. PLoS Genetics 4(4): e1000024.
Full Text & Related Files:
Abstract: The major histocompatibility complex (MHC) is one of the most extensively studied regions in the human genome because of the association of variants at this locus with autoimmune, infectious, and inflammatory diseases. However, identification of causal variants within the MHC for the majority of these diseases has remained difficult due to the great variability and extensive linkage disequilibrium (LD) that exists among alleles throughout this locus, coupled with inadequate study design whereby only a limited subset of about 20 from a total of approximately 250 genes have been studied in small cohorts of predominantly European origin. We have performed a review and pooled analysis of the past 30 years of research on the role of the MHC in six genetically complex disease traits – multiple sclerosis (MS), type 1 diabetes (T1D), systemic lupus erythematosus (SLE), ulcerative colitis (UC), Crohn's disease (CD), and rheumatoid arthritis (RA) – in order to consolidate and evaluate the current literature regarding MHC genetics in these common autoimmune and inflammatory diseases. We corroborate established MHC disease associations and identify predisposing variants that previously have not been appreciated. Furthermore, we find a number of interesting commonalities and differences across diseases that implicate both general and disease-specific pathogenetic mechanisms in autoimmunity.
Published Version: doi:10.1371/journal.pgen.1000024
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291482/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:8139238

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters