Identification of New Genetic Risk Variants for Type 2 Diabetes

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Identification of New Genetic Risk Variants for Type 2 Diabetes

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dc.contributor.author Shu, Xiao Ou
dc.contributor.author Long, Jirong
dc.contributor.author Cai, Qiuyin
dc.contributor.author Xiang, Yong-Bing
dc.contributor.author Tai, E. Shyong
dc.contributor.author Li, Xiangyang
dc.contributor.author Lin, Xu
dc.contributor.author Chow, Wong-Ho
dc.contributor.author Go, Min Jin
dc.contributor.author Seielstad, Mark
dc.contributor.author Li, Huaixing
dc.contributor.author Yu, Kai
dc.contributor.author Wen, Wanqing
dc.contributor.author Shi, Jiajun
dc.contributor.author Han, Bok-Ghee
dc.contributor.author Sim, Xue Ling
dc.contributor.author Liu, Liegang
dc.contributor.author Kim, Hyung-Lae
dc.contributor.author Ng, Daniel P. K.
dc.contributor.author Lee, Jong-Young
dc.contributor.author Gao, Yu-Tang
dc.contributor.author Visscher, Peter M.
dc.contributor.author Qi, Lu
dc.contributor.author Cho, Yoon-Jae
dc.contributor.author Bao, Wei
dc.contributor.author Cornelis, Marilyn
dc.contributor.author Qi, Qibin
dc.contributor.author Kim, Young Jin
dc.contributor.author Li, Chun
dc.contributor.author Zheng, Wei
dc.contributor.author Hu, Frank B.
dc.date.accessioned 2012-02-13T20:48:00Z
dc.date.issued 2010
dc.identifier.citation Shu, Xiao Ou, Jirong Long, Qiuyin Cai, Lu Qi, Yong-Bing Xiang, Yoon Shin Cho, E. Shyong Tai, et al. 2010. Identification of new genetic risk variants for type 2 diabetes. PLoS Genetics 6(9): e1001127. en_US
dc.identifier.issn 1553-7390 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:8160723
dc.description.abstract Although more than 20 genetic susceptibility loci have been reported for type 2 diabetes (T2D), most reported variants have small to moderate effects and account for only a small proportion of the heritability of T2D, suggesting that the majority of inter-person genetic variation in this disease remains to be determined. We conducted a multistage, genome-wide association study (GWAS) within the Asian Consortium of Diabetes to search for T2D susceptibility markers. From 590,887 SNPs genotyped in 1,019 T2D cases and 1,710 controls selected from Chinese women in Shanghai, we selected the top 2,100 SNPs that were not in linkage disequilibrium (r\(^2\) less than 0.2) with known T2D loci for in silico replication in three T2D GWAS conducted among European Americans, Koreans, and Singapore Chinese. The 5 most promising SNPs were genotyped in an independent set of 1,645 cases and 1,649 controls from Shanghai, and 4 of them were further genotyped in 1,487 cases and 3,316 controls from 2 additional Chinese studies. Consistent associations across all studies were found for rs1359790 (13q31.1), rs10906115 (10p13), and rs1436955 (15q22.2) with P-values (per allele OR, 95%CI) of 6.49×10\(^{−9}\) (1.15, 1.10–1.20), 1.45×10\(^{−8}\) (1.13, 1.08–1.18), and 7.14×10\(^{−7}\) (1.13, 1.08–1.19), respectively, in combined analyses of 9,794 cases and 14,615 controls. Our study provides strong evidence for a novel T2D susceptibility locus at 13q31.1 and the presence of new independent risk variants near regions (10p13 and 15q22.2) reported by previous GWAS. en_US
dc.language.iso en_US en_US
dc.publisher Public Library of Science en_US
dc.relation.isversionof doi:10.1371/journal.pgen.1001127 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2940731/pdf/ en_US
dash.license LAA
dc.subject gene discovery en_US
dc.subject genetics of disease en_US
dc.subject genetics and genomics en_US
dc.title Identification of New Genetic Risk Variants for Type 2 Diabetes en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal PLoS Genetics en_US
dash.depositing.author Qi, Lu
dc.date.available 2012-02-13T20:48:00Z
dash.affiliation.other HMS^Medicine-Brigham and Women's Hospital en_US
dash.affiliation.other SPH^Nutrition en_US
dash.affiliation.other SPH^Nutrition en_US
dash.affiliation.other HMS^Medicine-Brigham and Women's Hospital en_US
dash.affiliation.other SPH^Nutrition en_US

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